CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
革新肿瘤治疗：释放溶瘤病毒联合 CAR-T 细胞的潜力
英文原题：Revolutionizing Cancer Treatment: Unleashing the Power of Combining Oncolytic Viruses with CAR-T Cells.
查看英文原题
Revolutionizing Cancer Treatment: Unleashing the Power of Combining Oncolytic Viruses with CAR-T Cells.
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中文摘要
溶瘤病毒具有显著研究潜力且已有鼓舞性结果，是癌症治疗的新兴选择。病毒可深刻影响肿瘤微环境，对多种癌症产生作用。相比之下，CAR-T 治疗实体瘤疗效较低；将溶瘤病毒与CAR-T 联合是有前景的研究方向。溶瘤病毒有助形成抑制肿瘤的微环境，使CAR-T 能在实体恶性肿瘤中更有效发挥作用。本文全面分析溶瘤病毒和CAR-T 各自的优缺点，并重点讨论两者联合治疗的潜力。
展开英文摘要原文
Oncolytic Viruses (OVs) have emerged as a promising treatment option for cancer thanks to their significant research potential and encouraging results. These viruses exert a profound impact on the tumor microenvironment, making them effective against various types of cancer. In contrast, the efficacy of Chimeric antigen receptor (CAR)-T cell therapy in treating solid tumors is relatively low.
The combination of OVs and CAR-T cell therapy, however, is a promising area of research. OVs play a crucial role in enhancing the tumor-suppressive microenvironment, which in turn enables CAR-T cells to function efficiently in the context of solid malignancies. This review aims to provide a comprehensive analysis of the benefits and drawbacks of OV therapy and CAR-T cell therapy, with a focus on the potential of combining these two treatment approaches.
论文信息
- 作者
- Zhang L、Guo S、Chang S、Jiang G
- 单位
- Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China.China
- 文献类型
- 综述
- 期刊
- Anti-cancer agents in medicinal chemistry2024
- 原文标识
- PubMed 39051583 · DOI 10.2174/0118715206308253240723055019