CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞治疗后的急性肾损伤：流行病学、机制与预后
英文原题：Acute kidney injury following chimeric antigen receptor T-cell therapy: Epidemiology, mechanism and prognosis.
查看英文原题
Acute kidney injury following chimeric antigen receptor T-cell therapy: Epidemiology, mechanism and prognosis.
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中文摘要
CAR-T 治疗血液肿瘤后曾报告急性肾损伤，但其发生率、临床特征及预后尚不明确。本研究检索相关文献，纳入15项研究共694例患者。154例（22%）发生急性肾损伤，其中约58%为1期，约38%为2或3期，其余未报告分期。CRS被认为是最常见原因。发生急性肾损伤者中仅约10%接受肾脏替代治疗，多数经对症处理后肾功能恢复。CAR-T 后急性肾损伤总体较少且多为轻度，但临床医生仍需了解其机制并及时诊断和治疗。
展开英文摘要原文
Chimeric antigen receptor T cell (CAR-T) therapy is a promising treatment for hematologic tumors, and adverse events of acute kidney injury (AKI) have been reported.
However, its incidence, clinical characteristics, and prognosis remained unclear.
We searched PubMed, EMBASE, and Web of Science for study about AKI after CAR-T therapy, a total of 15 studies, comprising 694 patients, were included. Among the 694 patients, 154 (22%) developed AKI, of which 89 (57. 8%) were in stage 1, 59 (38. 3%) were in stage 2 or 3, and 6 (3. 9%) were not reported. Cytokine release syndrome is considered to be the most common cause of AKI.
Of the 154 AKI patients, only 16 (10. 4%) received renal replacement therapy, most AKI recovered renal function after symptomatic treatment. Although the occurrence of AKI after CAR-T therapy is rare and mostly mild, active knowledge of its pathogenesis, timely diagnosis and treatment are necessary for clinicians.
论文信息
- 作者
- Yang Y、Luo K、Xu G
- 第一作者单位
- Department of Nephrology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, PR China; Jiangxi Key Laboratory of Molecular Medicine, The Second Affiliated Hospital of Nanchang University, PR China.China
- 通讯作者单位
- Department of Nephrology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, PR China. Electronic address: gaosixu@163.com.China
- 文献类型
- 综述
- 期刊
- Clinical immunology (Orlando, Fla.)2024 Sep
- 原文标识
- PubMed 38996858 · DOI 10.1016/j.clim.2024.110311