CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞治疗幸存者的护理：文献综述
英文原题：Nursing care for chimeric antigen receptor T cell therapy survivors: A literature review.
查看英文原题
Nursing care for chimeric antigen receptor T cell therapy survivors: A literature review.
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中文摘要
CAR-T 通过基因改造患者自身T细胞，使其表达嵌合抗原受体并识别、杀伤癌细胞，已改善血液恶性肿瘤预后并增加长期生存者。然而，这一疗法出现时间较近，晚期后遗症及治疗后护理证据有限。CAR-T 快速发展为高级执业护士提供了重要角色，包括协调照护、开展患者教育和维护长期生存者健康。本文概述CAR-T 长期生存者面临的身体、心理社会和经济挑战，并提出全面的护理计划以应对这些问题。
展开英文摘要原文
Chimeric antigen receptor T cell (CAR-T) therapy is an immunotherapy that involves genetically modifying the patient's own T cells to express a chimeric antigen receptor, enabling them to recognize and destroy cancer cells. This treatment has revolutionized the prognosis and management of hematological malignancies, leading to a significant increase in long-term survivors.
However, there is limited evidence regarding late sequelae and post-treatment care due to the recent emergence of this therapy. The rapid advancement of CAR-T therapies has created opportunities for advanced practice nurses to play a crucial role in coordinating care, providing education, and ensuring the ongoing well-being of survivors. This article provides an overview of the physical, psychosocial, and financial challenges faced by long-term survivors of CAR-T therapy and proposes a comprehensive nursing care plan to address these issues.
论文信息
- 作者
- Montoro-Lorite M、Moreno C、Ramos C、Solano MT、Lahoz S、Bonilla-Serrano C、Domènech A、Ayora P
- 单位
- Institute of Cancer and Blood Diseases, Hospital Clínic de Barcelona, Barcelona, Spain.Spain
- 文献类型
- 综述
- 期刊
- Asia-Pacific journal of oncology nursing2024 Jun
- 原文标识
- PubMed 38975609 · DOI 10.1016/j.apjon.2024.100495
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