CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞治疗后铁蛋白评估的诊断陷阱：认识钩状效应
英文原题：Diagnostic pitfalls in assessment of ferritin following CAR-T-cell therapy: Understanding the hook effect.
查看英文原题
Diagnostic pitfalls in assessment of ferritin following CAR-T-cell therapy: Understanding the hook effect.
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中文摘要
钩状效应是一种已知但临床上常被忽视的免疫测定干扰，过量分析物会导致结果假性偏低。本文报告一名27岁患者出现免疫效应细胞相关噬血细胞性淋巴组织细胞增多症样综合征，其铁蛋白结果在参考实验室检测时比本院稀释后检测低逾1000倍。该病例提示临床人员需了解钩状效应对铁蛋白测量的影响；若临床症状与实验室结果不符，应及时与检验科沟通。
展开英文摘要原文
The hook effect is a well-described but clinically underappreciated immunoassay interference, where a falsely lowered result is caused by analyte excess.
We describe a situation in which ferritin immunoassay results from a 27-year-old female with immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome were more than 1000 times lower at a reference laboratory than those determined in-house after dilution. This case underscores the importance for clinical care providers to be aware of the impact of the hook effect on ferritin measurements, and to promptly communicate with the laboratory when there are discrepancies between clinical symptoms and test results.
论文信息
- 作者
- Harb R、Coverdell TC、Shalabi H、Shah NN
- 第一作者单位
- Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.United States
- 通讯作者单位
- Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.United States
- 文献类型
- 病例报告
- 期刊
- Pediatric blood & cancer2024 Sep
- 原文标识
- PubMed 38961599 · DOI 10.1002/pbc.31171
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