CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
伴多形性双核浆细胞新型增殖的间变性多发性骨髓瘤
英文原题：Anaplastic Multiple Myeloma With a Novel Proliferation of Pleomorphic Binuclear Plasma Cells.
查看英文原题
Anaplastic Multiple Myeloma With a Novel Proliferation of Pleomorphic Binuclear Plasma Cells.
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中文摘要
本文报告一例多发性骨髓瘤进展为胸腔积液中间变性骨髓瘤的罕见病例。胸腔积液瑞氏染色细胞离心涂片显示，以具有多形性细胞核的单核浆细胞为主，其核大小不一，符合间变性骨髓瘤形态；同时还见较多具有多形性细胞核的双核浆细胞。形态计量分析显示，相较小核，单核浆细胞大核平均长度为1.9倍，双核浆细胞为2.3倍。患者因疾病复发接受BCMA CAR-T 治疗，治疗第51天血清单克隆副蛋白显著下降。病理医师应知晓，多形性双核浆细胞也可属于间变性骨髓瘤的形态谱。
展开英文摘要原文
This study describes an unusual case of multiple myeloma that progressed to anaplastic multiple myeloma in the pleural fluid. The Wright-stained cytospin of the pleural fluid showed a predominant population of mononuclear plasma cells with pleomorphic nuclei, characterized by both small and large nuclei, which is typical of anaplastic multiple myeloma.
However, there were also more binuclear plasma cells with pleomorphic nuclei. Morphometric analysis showed that the mean nuclear length was 1. 9-fold and 2. 3-fold higher in the large nuclei compared to the small nuclei for the mononuclear plasma cells and binuclear plasma cells, respectively (p<0. 001).
The patient received B cell maturation antigen chimeric antigen receptor T cell (CAR-T) therapy for relapsed disease, with a significant reduction of the serum monoclonal paraprotein level at day 51 post-therapy. Pathologists should be aware that pleomorphic binuclear plasma cells can be part of the morphologic spectrum in anaplastic multiple myeloma.
论文信息
- 作者
- Cunningham MT、Farrell D、Mostofizadeh S、Chopra S
- 单位
- Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, USA.United States
- 文献类型
- 病例报告
- 期刊
- Cureus2024 Jul
- 原文标识
- PubMed 38957510 · DOI 10.7759/cureus.63597
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