CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
抗 BCMA CAR-T 治疗伴髓外病变的多发性骨髓瘤：病例报告及文献复习
英文原题：Anti-BCMA CAR-T therapy for multiple myeloma with extramedullary disease: A case report and review of the literature.
查看英文原题
Anti-BCMA CAR-T therapy for multiple myeloma with extramedullary disease: A case report and review of the literature.
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研究概要
伴髓外病变的 MM 治疗选择往往有限，传统化疗方法无效；然而，BCMA CAR-T 细胞治疗可显著改善 MM 髓外病变的症状。
中文摘要
髓外病变型多发性骨髓瘤较少见，BCMA CAR-T 是血液恶性肿瘤的新疗法，关于其治疗髓外病变的报道有限。本文报告一例患者：66岁女性因左上颌牙龈增大就诊，诊断为伴髓外病变的惰性III期多发性骨髓瘤。患者参加人源化抗BCMA CAR-T 临床试验后，症状改善，左侧牙龈增生和肿胀、颊部肿块及颈部和颌下肿块均消退。脱落肿块病理检查显示坏死组织。髓外病变型多发性骨髓瘤治疗选择有限且传统化疗效果欠佳；该病例提示BCMA CAR-T 可显著改善相关症状。
展开英文摘要原文
RESULTS
Symptoms improved; left gingival hyperplasia and swelling resolved; left buccal mass resolved; and neck and submandibular masses resolved. Pathological examination of the exfoliated masses showed necrotic tissue.
CONCLUSION
MM with extramedullary lesions often has limited treatment options, and traditional chemotherapy methods are ineffective; however, BCMA CAR-T cell therapy can significantly improve the symptoms of extramedullary lesions in MM.
论文信息
- 作者
- Shi H、Zhang M、Su Y、Liu J、Guo J、Liu M、Ma Q
- 单位
- Second Clinical College of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, China.China
- 文献类型
- 病例报告 · 综述
- 期刊
- Medicine2024 Jun 28
- 原文标识
- PubMed 38941416 · DOI 10.1097/MD.0000000000038541
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →