CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
免疫原性细胞死亡在肿瘤免疫治疗中的新兴作用：通过联合策略推进下一代 CAR-T 细胞免疫治疗
英文原题：Emerging role of immunogenic cell death in cancer immunotherapy: Advancing next-generation CAR-T cell immunotherapy by combination.
查看英文原题
Emerging role of immunogenic cell death in cancer immunotherapy: Advancing next-generation CAR-T cell immunotherapy by combination.
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中文摘要
免疫原性细胞死亡（ICD）是一种由应激驱动的调节性细胞死亡形式，死亡肿瘤细胞会激活特定信号并释放损伤相关分子模式，从而引发强烈抗肿瘤免疫，并可能将肿瘤免疫微环境从“冷”转为“热”。CAR-T 作为抗肿瘤免疫治疗的重要突破，在血液恶性肿瘤中作用显著，但用于实体瘤仍受限。实体瘤CAR-T 面临的难题包括肿瘤抗原异质或缺失，以及肿瘤的物理屏障和免疫屏障。诱导ICD的治疗与CAR-T 联合，有望扩大CAR-T 在实体瘤中的应用。本文综述ICD特征及应激响应机制，并总结多种基于ICD的疗法与CAR-T 协同增强抗肿瘤能力的研究。
展开英文摘要原文
Immunogenic cell death (ICD) is a stress-driven form of regulated cell death (RCD) in which dying tumor cells' specific signaling pathways are activated to release damage-associated molecular patterns (DAMPs), leading to the robust anti-tumor immune response as well as a reversal of the tumor immune microenvironment from "cold" to "hot". Chimeric antigen receptor (CAR)-T cell therapy, as a landmark in anti-tumor immunotherapy, plays a formidable role in hematologic malignancies but falls short in solid tumors.
The Gordian knot of CAR-T cells for solid tumors includes but is not limited to, tumor antigen heterogeneity or absence, physical and immune barriers of tumors. The combination of ICD induction therapy and CAR-T cell immunotherapy is expected to promote the intensive use of CAR-T cell in solid tumors. In this review, we summarize the characteristics of ICD, stress-responsive mechanism, and the synergistic effect of various ICD-based therapies with CAR-T cells to effectively improve anti-tumor capacity.
论文信息
- 作者
- Zhou Z、Mai Y、Zhang G、Wang Y、Sun P、Jing Z、Li Z、Xu Y
- 第一作者单位
- Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.China
- 通讯作者单位
- Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. Electronic address: fccliuj@zzu.edu.cn.China
- 文献类型
- 综述
- 期刊
- Cancer letters2024 Aug 28
- 原文标识
- PubMed 38936505 · DOI 10.1016/j.canlet.2024.217079