CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
经典 CAR-T 细胞之外的 CAR 细胞：功能特性与应用前景
英文原题：CAR Cells beyond Classical CAR T Cells: Functional Properties and Prospects of Application.
查看英文原题
CAR Cells beyond Classical CAR T Cells: Functional Properties and Prospects of Application.
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中文摘要
嵌合抗原受体（CAR）是经基因工程改造的受体，可识别抗原并激活细胞内信号级联反应。CAR 不同结构域来源于不同蛋白质，共同介导信号识别和传递。携带靶向肿瘤相关抗原 CAR 的 T 细胞已用于开发 CAR-T 细胞疗法，这是对抗恶性肿瘤的一种新方法。尽管 CAR-T 细胞疗法治疗肿瘤血液病疗效很高，但也存在若干缺点，采用其他类型白细胞作为效应细胞可能有助于避免这些问题。CAR 可在多种适应性和先天免疫细胞中表达，从而赋予或增强其细胞毒特性。本综述讨论 CAR 在不同类型免疫细胞中的功能特征，重点介绍潜在 CAR 细胞产品临床前和临床疗效研究结果及其安全性。
展开英文摘要原文
Chimeric antigen receptors (CARs) are genetically engineered receptors that recognize antigens and activate signaling cascades in a cell. Signal recognition and transmission are mediated by the CAR domains derived from different proteins. T cells carrying CARs against tumor-associated antigens have been used in the development of the CAR T cell therapy, a new approach to fighting malignant neoplasms.
Despite its high efficacy in the treatment of oncohematological diseases, CAR T cell therapy has a number of disadvantages that could be avoided by using other types of leukocytes as effector cells. CARs can be expressed in a wide range of cells of adaptive and innate immunity with the emergence or improvement of cytotoxic properties. This review discusses the features of CAR function in different types of immune cells, with a particular focus on the results of preclinical and clinical efficacy studies and the safety of potential CAR cell products.
论文信息
- 作者
- Minina EP、Dianov DV、Sheetikov SA、Bogolyubova AV
- 第一作者单位
- National Medical Research Centre for Hematology, Ministry of Health of the Russian Federation, Moscow, 125167, Russia.Russia
- 通讯作者单位
- National Medical Research Centre for Hematology, Ministry of Health of the Russian Federation, Moscow, 125167, Russia. apollinariya.bogolyubova@gmail.com.Russia
- 文献类型
- 综述
- 期刊
- Biochemistry. Biokhimiia2024 May
- 原文标识
- PubMed 38880641 · DOI 10.1134/S0006297924050018