CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞疗法治疗血液系统恶性肿瘤的空前成功
英文原题：The Unprecedented Success of Chimeric Antigen Receptor T-Cell Therapy in the Treatment of Hematological Malignancies.
查看英文原题
The Unprecedented Success of Chimeric Antigen Receptor T-Cell Therapy in the Treatment of Hematological Malignancies.
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中文摘要
嵌合抗原受体（CAR）疗法是血液系统恶性肿瘤、尤其是 B 细胞恶性肿瘤治疗领域最具突破性的进展之一。这一疗法成功的基本理念是生成一种合成蛋白（CAR），使其能够引导 T 淋巴细胞攻击癌细胞。近年来，对血液系统恶性肿瘤遗传和分子基础的新认识推动了靶向治疗的发展。CAR-T 细胞疗法是此类免疫治疗技术之一，近期受到广泛关注，为有效治疗复发/难治性血液系统恶性肿瘤及部分实体恶性肿瘤带来了希望。当下的研究人员或许无法预知 CAR-T 细胞疗法的未来，但迄今已有研究表明，尽管存在局限，该疗法仍取得成功；可以认为，其应用范围正日益扩大。
展开英文摘要原文
Chimeric antigen receptor (CAR) therapy is one of the most unprecedented advancements in the treatment of hematological malignancies, especially B-cell malignancies. The fundamental notion behind the success of this therapy is to generate a synthetic protein (CAR) capable of redirecting T lymphocytes to act against cancer cells. New insights into the genetic and molecular base of hematological malignancies have more recently given rise to the development of targeted treatments.
CAR T-cell therapy is one of these immunological treatment techniques that has recently received a lot of attention and paved a light of hope for the effective cure of relapsed and refractory hematological malignancies and some solid malignancies. Researchers of today might not know what the future holds for CAR T-cell therapy, but from whatever research has been done so far, this therapy has proven to be a success despite its limitations, and it can be assumed that the spectrum of its application is expanding with each passing day.
论文信息
- 作者
- Dhaliwal S、Gill FS、Hamid P
- 第一作者单位
- Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.United States
- 通讯作者单位
- Neurology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.United States
- 文献类型
- 综述
- 期刊
- Cureus2024 May
- 原文标识
- PubMed 38854249 · DOI 10.7759/cureus.59951
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