RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR 巨噬细胞调控抗癌治疗的免疫交响乐
英文原题：CAR macrophages tuning the immune symphony of anti-cancer therapies.
查看英文原题
CAR macrophages tuning the immune symphony of anti-cancer therapies.
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中文摘要
嵌合抗原受体（CAR）巨噬细胞拓宽了抗癌免疫治疗的版图，以对抗实体恶性肿瘤。Shah等人引入CAR以促进CAR巨噬细胞疗法，该疗法旨在招募并激活T/NK 细胞，进一步加强整体免疫反应，以减轻胰腺癌负荷和转移扩散。
展开英文摘要原文
Chimeric antigen receptor (CAR) macrophages have broadened the landscape of anti-cancer immunotherapies to combat solid malignancies. Shah et al. introduce CARs to facilitate a CAR macrophage therapy, which aims to recruit and activate T/natural killer cells, further strengthening the overall immune response to decrease pancreatic cancer burden and metastatic spreading.
论文信息
- 作者
- Paasch D、Lachmann N
- 第一作者单位
- Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany.Germany
- 通讯作者单位
- Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany; RESIST, Cluster of Excellence, Hannover Medical School, 30625 Hannover, Germany; Biomedical Research in End Stage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany; Center of Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, 30625 Hannover, Germany. Electronic address: lachmann.nico@mh-hannover.de.Germany
- 文献类型
- 评论
- 期刊
- Cell stem cell2024 Jun 6
- 原文标识
- PubMed 38848684 · DOI 10.1016/j.stem.2024.05.006