RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
小分子也能成大事：靶向 PTPN2/PTPN1 的小分子抑制剂用于肿瘤免疫治疗
英文原题：Little ones can do big things: Small molecule inhibitors target PTPN2/PTPN1 for tumor immunotherapy.
查看英文原题
Little ones can do big things: Small molecule inhibitors target PTPN2/PTPN1 for tumor immunotherapy.
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中文摘要
AC484是基于PTPN2蛋白结构设计化合物而开发的。AC484通过多种机制增强抗肿瘤免疫：增加肿瘤对IFN-γ的敏感性、改善T细胞功能、刺激肿瘤微环境炎症、扩大TCR多样性以及防止T细胞耗竭。有趣的是，AC484的疗效也由CD8+和NK细胞介导。
展开英文摘要原文
AC484 was developed by designing compounds based on the PTPN2 protein structure. AC484 enhances antitumor immunity through multiple mechanisms: increasing tumor sensitivity to IFN-γ, improving T-cell functions, stimulating tumor microenvironment inflammation, expanding TCR diversity, and preventing T-cell exhaustion. Interestingly, the efficacy of AC484 was also mediated by CD8+ and NK cells.
论文信息
- 作者
- Wang J、Qin S、Zhang A
- 单位
- Department of Rehabilitation Medicine Shanghai Fourth People's Hospital, School of Medicine, Tongji University Shanghai China.China
- 期刊
- MedComm2024 Jun
- 原文标识
- PubMed 38817652 · DOI 10.1002/mco2.567
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