CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
肿瘤微环境中的非肿瘤细胞——胶质母细胞瘤发病机制的“幕后推手”及潜在治疗靶点
英文原题：Non-Tumor Cells within the Tumor Microenvironment-The "Eminence Grise" of the Glioblastoma Pathogenesis and Potential Targets for Therapy.
查看英文原题
Non-Tumor Cells within the Tumor Microenvironment-The "Eminence Grise" of the Glioblastoma Pathogenesis and Potential Targets for Therapy.
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中文摘要
胶质母细胞瘤（GBM）是成人中枢神经系统最常见的恶性肿瘤。GBM治疗失败率高，预后通常极差。肿瘤细胞的表型异质性、GBM肿瘤微环境（TME）中非肿瘤细胞群体的动态复杂性及其双向交互作用，共同构成了当前治疗方法的挑战。本文中，我们讨论GBM的病因，并描述其TME中几种主要类型的非肿瘤细胞、它们对GBM发病机制的影响以及这种影响的分子机制。我们还结合该领域最新研究，讨论它们作为潜在治疗靶点或预后生物标志物的价值。我们得出结论：除非将TME内所有“关键参与者”非肿瘤细胞群体都纳入考量，否则GBM治疗开发不可能取得突破。
展开英文摘要原文
Glioblastoma (GBM) is the most common malignancy of the central nervous system in adults. GBM has high levels of therapy failure and its prognosis is usually dismal. The phenotypic heterogeneity of the tumor cells, dynamic complexity of non-tumor cell populations within the GBM tumor microenvironment (TME), and their bi-directional cross-talk contribute to the challenges of current therapeutic approaches.
Herein, we discuss the etiology of GBM, and describe several major types of non-tumor cells within its TME, their impact on GBM pathogenesis, and molecular mechanisms of such an impact.
We also discuss their value as potential therapeutic targets or prognostic biomarkers, with reference to the most recent works on this subject.
We conclude that unless all "key player" populations of non-tumor cells within the TME are considered, no breakthrough in developing treatment for GBM can be achieved.
论文信息
- 作者
- Bugakova AS、Chudakova DA、Myzina MS、Yanysheva EP、Ozerskaya IV、Soboleva AV、Baklaushev VP、Yusubalieva GM
- 单位
- Federal Center for Brain and Neurotechnologies, Federal Medical and Biological Agency of Russia, 117513 Moscow, Russia.Russia
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Cells2024 May 9
- 原文标识
- PubMed 38786032 · DOI 10.3390/cells13100808
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