CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
肿瘤代谢改变及其对下一代 CAR-T 细胞治疗的启示
英文原题：Altered cancer metabolism and implications for next-generation CAR T-cell therapies.
查看英文原题
Altered cancer metabolism and implications for next-generation CAR T-cell therapies.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
本综述深入审视嵌合抗原受体（CAR）T 细胞治疗实体瘤的不断发展领域，特别关注肿瘤微环境中的代谢挑战。CAR-T 治疗血液系统恶性肿瘤取得显著成功，但用于实体瘤仍受到限制。重要障碍是肿瘤微环境具有敌对性，会损害 CAR-T 的存活和功能。本综述探讨癌细胞代谢适应及其对免疫细胞的影响，强调营养物质竞争和免疫抑制性代谢物积累。文章还介绍增强 CAR-T 代谢适应性和持久性的新兴策略，包括基因工程和代谢重编程。将代谢干预与 CAR-T 联合的综合策略有望克服这些限制并改善实体瘤治疗结局。
展开英文摘要原文
This review critically examines the evolving landscape of chimeric antigen receptor (CAR) T-cell therapy in treating solid tumors, with a particular focus on the metabolic challenges within the tumor microenvironment. CAR T-cell therapy has demonstrated remarkable success in hematologic malignancies, yet its efficacy in solid tumors remains limited. A significant barrier is the hostile milieu of the tumor microenvironment, which impairs CAR T-cell survival and function.
This review delves into the metabolic adaptations of cancer cells and their impact on immune cells, highlighting the competition for nutrients and the accumulation of immunosuppressive metabolites. It also explores emerging strategies to enhance CAR T-cell metabolic fitness and persistence, including genetic engineering and metabolic reprogramming. An integrated approach, combining metabolic interventions with CAR T-cell therapy, has the potential to overcome these constraints and improve therapeutic outcomes in solid tumors.
论文信息
- 作者
- Ramapriyan R、Vykunta VS、Vandecandelaere G、Richardson LGK、Sun J、Curry WT、Choi BD
- 第一作者单位
- Brain Tumor Immunotherapy Laboratory, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: rramapriyan@mgh.harvard.edu.United States
- 通讯作者单位
- Brain Tumor Immunotherapy Laboratory, Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: bchoi@mgh.harvard.edu.United States
- 文献类型
- 综述 · 美国 NIH 资助研究 · 非美国政府资助研究
- 期刊
- Pharmacology & therapeutics2024 Jul
- 原文标识
- PubMed 38763321 · DOI 10.1016/j.pharmthera.2024.108667