RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
放化疗对胶质母细胞瘤外周免疫应答的影响
英文原题：Effect of radiochemotherapy on peripheral immune response in glioblastoma.
查看英文原题
Effect of radiochemotherapy on peripheral immune response in glioblastoma.
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研究概要
这些发现揭示了 GBM 中的外周免疫格局，强调治疗的免疫抑制作用。
中文摘要
背景
胶质母细胞瘤（GBM）是一种预后极差的原发性脑肿瘤，常对免疫治疗耐药并伴随免疫抑制。本研究旨在评估类固醇和 Stupp 方案治疗对 GBM 患者外周血免疫参数的影响及其与临床结局的关系。
方法
使用流式细胞术组合面板和 Bio-Plex 检测，分析 54 例 GBM 患者和 21 名健康志愿者的免疫表型及血清细胞因子。
结果
GBM 患者淋巴系细胞（CD4、CD8 T 和 NKT 细胞）数量减少，免疫检查点表达升高，髓系细胞（尤其是中性粒细胞）数量增加，促炎细胞因子水平也升高。类固醇使用会减少 T 细胞和 NK 细胞数量；放化疗则导致淋巴系细胞减少、髓系细胞增多和免疫检查点表达升高。研究识别出若干可能预测结局的免疫细胞亚群。
结论
这些发现揭示 GBM 外周免疫特征，强调治疗的免疫抑制效应。基线免疫参数可能成为预测治疗应答的预后指标。
展开英文摘要原文
BACKGROUND
Glioblastoma (GBM) is a primary brain tumor with a dismal prognosis, often resistant to immunotherapy and associated with immune suppression. This study aimed to assess the impact of steroids and Stupp-regimen treatment on peripheral blood immune parameters in GBM patients and their association with outcomes.
METHODS
Using cytometry panels and bioplex assays, we analyzed the immune phenotype and serum cytokines of 54 GBM patients and 21 healthy volunteers.
RESULTS
GBM patients exhibited decreased lymphoid cell numbers (CD4, CD8 T cells, NKT cells) with heightened immune checkpoint expression and increased myeloid cell numbers (especially neutrophils), along with elevated pro-inflammatory cytokine levels. Steroid use decreased T and NK cell numbers, while radio-chemotherapy led to decreased lymphoid cell numbers, increased myeloid cell numbers, and heightened immune checkpoint expression. Certain immune cell subsets were identified as potential outcome predictors.
CONCLUSION
Overall, these findings shed light on the peripheral immune landscape in GBM, emphasizing the immunosuppressive effects of treatment. Baseline immune parameters may serve as prognostic indicators for treatment response.
论文信息
- 作者
- Hampe L、Daumoine S、Limagne E、Roussot N、Borsotti F、Vincent J、Ilie S、Truntzer C
- 第一作者单位
- University Bourgogne Franche-Comté, Dijon, France.France
- 通讯作者单位
- University Bourgogne Franche-Comté, Dijon, France. mthibaudin@cgfl.fr.France
- 期刊
- Cancer immunology, immunotherapy : CII2024 May 16
- 原文标识
- PubMed 38753169 · DOI 10.1007/s00262-024-03722-5
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