CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
超声在肿瘤免疫治疗中的进展
英文原题：Advances of ultrasound in tumor immunotherapy.
查看英文原题
Advances of ultrasound in tumor immunotherapy.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
免疫疗法已成为治疗肿瘤的一种革命性方法，为全世界的癌症患者带来了新的希望。检查点抑制剂、CAR-T 细胞疗法和癌症疫苗等免疫治疗策略在临床试验中显示出巨大潜力。尽管结果令人鼓舞，但仍存在限制免疫疗法整体效果的局限性；免疫治疗的反应不均衡，患者的缓解率仍然较低，且伴有肿瘤细胞免疫逃逸的全身免疫毒性很常见。超声技术近年来发展迅速，已成为肿瘤免疫治疗的重要参与者。高强度聚焦超声和超声刺激微泡的引入为抗击肿瘤的新治疗策略开辟了道路。本文探讨了超声联合免疫疗法在这一特定领域的革命性进展。
展开英文摘要原文
Immunotherapy has become a revolutionary method for treating tumors, offering new hope to cancer patients worldwide. Immunotherapy strategies such as checkpoint inhibitors, chimeric antigen receptor T-cell (CAR-T) therapy, and cancer vaccines have shown significant potential in clinical trials. Despite the promising results, there are still limitations that impede the overall effectiveness of immunotherapy; the response to immunotherapy is uneven, the response rate of patients is still low, and systemic immune toxicity accompanied with tumor cell immune evasion is common.
Ultrasound technology has evolved rapidly in recent years and has become a significant player in tumor immunotherapy. The introductions of high intensity focused ultrasound and ultrasound-stimulated microbubbles have opened doors for new therapeutic strategies in the fight against tumor. This paper explores the revolutionary advancements of ultrasound combined with immunotherapy in this particular field.
论文信息
- 作者
- Lin J、Wu Y、Liu G、Cui R、Xu Y
- 第一作者单位
- Department of Ultrasound, Guangdong Provincial Hospital of Chinese Medicine-Zhuhai Hospital, Zhuhai, PR China. Electronic address: fairy_linjing@126.com.China
- 通讯作者单位
- Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macao, PR China; Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute, Hengqin, Zhuhai, PR China. Electronic address: yhxu@must.edu.mo.China
- 文献类型
- 综述
- 期刊
- International immunopharmacology2024 Jun 15
- 原文标识
- PubMed 38735256 · DOI 10.1016/j.intimp.2024.112233