CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
用于预测 HER2 阳性乳腺癌中 CD8 阳性淋巴细胞状态的影像学特征
英文原题：Radiological Features for Predicting the Status of CD8-Positive Lymphocytes in HER2 Positive Breast Cancer.
查看英文原题
Radiological Features for Predicting the Status of CD8-Positive Lymphocytes in HER2 Positive Breast Cancer.
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研究概要
超声特征（形态、方向及后方回声）与 ADC 值可能是评估 HER2 阳性乳腺癌中 CD8⁺ TIL 水平的有价值工具。
中文摘要
人表皮生长因子受体 2（HER2）阳性乳腺癌（BC）中，TIL（肿瘤浸润淋巴细胞）水平与病理完全缓解呈正相关。
研究 HER2 阳性 BC 患者超声（US）和磁共振成像（MRI）特征与 CD8 阳性 TIL（CD8+-TIL）水平之间的关系。 研究设计：回顾性队列研究。
本研究纳入 155 例连续 HER2 阳性女性 BC 患者，分为 CD8+-TIL 低水平组（<35%）和高水平组（≥35%）。依据 BI-RADS 词典评估 US 和 MRI 特征，并使用 RadiAnt 软件计算表观扩散系数（ADC）。通过单变量和多变量分析确定用于预测 CD8+-TIL 水平的最佳 US 和 MRI 特征。采用 ROC 分析和 DeLong 检验比较 US 与 MRI 特征的诊断效能，并建立列线图以提升临床应用价值。
US 单变量分析显示，两组在形状、方向和后方回声方面差异显著；边缘、内部回声和微钙化则无显著差异。多因素分析发现形状、方向和后方回声为独立危险因素，OR 分别为 11.62、2.70 和 0.16。MRI 特征中，ADC 是 CD8+-TIL 水平的独立预测因子。三项 US 特征和 ADC 的表现良好，AUC 分别为 0.802 和 0.705。US 与 ADC 联合预测效能更高（AUC=0.888），优于单独 US 或 ADC（US_ADC 与 US 比较 P=0.009；US_ADC 与 ADC 比较 P<0.001）。
形状、方向、后方回声等 US 特征及 ADC 值可用于评估 HER2 阳性 BC 的 CD8+-TIL 水平。列线图可能有助于临床决策。
展开英文摘要原文
The level of tumor-infiltrating lymphocytes (TILs) in human epidermal growth factor receptor type 2 (HER2)-positive breast cancer (BC) is positively correlated with pathological complete response. AIMS: To investigate the relationship between ultrasound (US) and magnetic resonance imaging (MRI) features and the level of CD8-positive TILs (CD8 + -TILs) in patients with HER2-positive BC. STUDY DESIGN: Retrospective cohort study.
This retrospective study included 155 consecutive women with HER2-positive BC. Patients were divided into two groups: CD8 + -TIL low (< 35%) and CD8 + -TIL high ( 35%) groups. US and MRI features were evaluated using the BI-RADS lexicon, and the apparent diffusion coefficient (ADC) value was calculated using RadiAnt software. Univariate and multivariate analyses revealed the optimal US and MRI features for predicting CD8 + -TIL levels. Receiver operating characteristic analysis and the Delong test were used to compare the diagnostic performance of US and MRI features. Furthermore, implementing a nomogram will increase clinical utility.
Univariate analysis of US features showed significant differences in shape, orientation, and posterior echo between the two groups; however, there were no significant differences in margins, internal echo, and microcalcification. Multifactorial analysis revealed that shape, orientation, and posterior echo were independent risk factors, with odds ratios of 11.62, 2.70, and 0.16, respectively. In terms of MRI features, ADC was an independent predictor of CD8 + -TIL levels. These three US features and the ADC performed well, with area under the curve (AUC) values of 0.802 and 0.705, respectively. The combination of US and ADC values had higher predictive efficacy (AUC = 0.888) than either US or ADC alone ( p = 0.009, US_ADC vs. US; p < 0.001, US_ADC vs. ADC).
US features (shape, orientation, and posterior echo) and ADC value may be a valuable tool for estimating CD8 + -TIL levels in HER2-positive BC. The nomogram may help clinicians in making decisions.
论文信息
- 作者
- Fan Y、Li X、Zhong P、Guo H、Han D、Tian W、Fang J
- 单位
- Department of Ultrasound Diagnosis, Daping Hospital, Army Medical University, Chongqing, China.China
- 文献类型
- 非美国政府资助研究
- 期刊
- Balkan medical journal2024 May 3
- 原文标识
- PubMed 38700366 · DOI 10.4274/balkanmedj.galenos.2024.2024-2-64
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