RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
短期非手术牙周治疗可提高白细胞介素-12 水平并降低口腔癌风险
英文原题：Short-term, nonsurgical periodontal therapy boosts interleukin-12 levels and reduces oral cancer risk.
查看英文原题
Short-term, nonsurgical periodontal therapy boosts interleukin-12 levels and reduces oral cancer risk.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
研究概要
NST 对全科牙医而言是一种经济有效且易于实施的癌症预防措施。
研究思路结论见上方概要
背景
细胞因子，包括白细胞介素-12（IL-12），是调节细胞存活、增殖、分化和功能的蛋白质。IL-12是一种异二聚体促炎细胞因子。它具有杀肿瘤特性，并促进M1巨噬细胞极化以及辅助性T（Th1）细胞产生IFN-γ，进而刺激抗肿瘤细胞毒性CD8+和NK 细胞，从而激活针对肿瘤细胞的效应免疫应答。
方法
本文评估了60例广泛性慢性牙周炎（GCP）患者的IL-2水平。报告的临床指标包括菌斑指数、牙龈指数、牙周袋探诊深度、探诊出血百分比（BOP %）和临床附着丧失。
结果
预处理组GCP患者的平均IL-12水平显著低于治疗后组。短期非手术治疗（NST）可显著改善牙周指数并提高IL-12水平，从而降低口腔癌风险。
展开英文摘要原文
BACKGROUND
Cytokines, including interleukin-12 (IL-12), are proteins that regulate cell survival, proliferation, differentiation, and function. IL-12 is a heterodimeric proinflammatory cytokine. It possesses tumoricidal properties and promotes M1 macrophage polarization and IFN-γ production by T helper (Th1) cells, which in turn stimulates the antitumor cytotoxic cluster of eight positive (CD8+) and natural killer cells, therefore activating an effector immune response against tumor cells.
MATERIALS AND METHODS
Herein, the IL-2 levels of 60 patients with generalized chronic periodontitis (GCP) were assessed. Plaque index, gingival index, pocket probing depth, bleeding on probing percentage (BOP %), and clinical attachment loss were the clinical indicators reported.
RESULTS
Patients with GCP in the pretreatment group had substantially lower mean IL-12 levels than those in the post-treatment group. Short-term, nonsurgical treatment (NST) considerably improved periodontal indices and increased IL-12 levels, thereby reducing oral cancer risk.
CONCLUSION
NST is a cost-effective and accessible cancer prevention procedure for general dentists.
论文信息
- 作者
- Alhobeira HA、Sharma A、Sharma A、Khan M、Lohani M、Khan S、Fahmy EK、Esmaeel SE
- 第一作者单位
- Department of Restorative Dentistry, College of Dentistry, University of Ha'il, Ha'il 55473, Saudi Arabia.Saudi Arabia
- 通讯作者单位
- Department of Dentistry, LLRM Medical College, CCS University Meerut, Meerut, 250002, UP, India. profanamika091@gmail.com.India
- 期刊
- Irish journal of medical science2024 Aug
- 原文标识
- PubMed 38698250 · DOI 10.1007/s11845-024-03695-5