CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 治疗后经 (18)F-FDG PET/CT 检出的儿童 B 细胞急性淋巴细胞白血病乳腺复发
英文原题：Breast Relapse of Pediatric B-Cell Acute Lymphoblastic Leukemia After CAR-T Therapy Detected by (18)F-FDG PET/CT.
查看英文原题
Breast Relapse of Pediatric B-Cell Acute Lymphoblastic Leukemia After CAR-T Therapy Detected by (18)F-FDG PET/CT.
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研究概要
据我们所知，这是首例关于儿童 B-ALL 患者在 CAR-T 治疗后出现孤立且隐匿性乳腺复发的报告，该复发在疾病监测期间通过 18 F-FDG PET/CT 早期发现。
研究思路结论见上方概要
背景
B细胞急性淋巴细胞白血病（B-ALL）是儿童最常见的恶性肿瘤。在采用标准化疗免疫疗法以及近年来嵌合抗原受体（CAR）-T细胞治疗的B-ALL儿科患者中，髓内和髓外疾病复发是众所周知的现象。18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）作为一种敏感的影像学工具，用于检测髓外部位的疾病复发，但在CAR-T 治疗背景下的文献证据有限。病例报告：一名12岁女性因B-ALL复发接受CAR-T 治疗，在疾病缓解后进行监测性18F-FDG PET/CT扫描，检测到乳腺实质中一处孤立且临床隐匿的复发灶，并经组织学证实。
展开英文摘要原文
BACKGROUND
B-cell acute lymphoblastic leukemia (B-ALL) is the most common childhood malignancy. Medullary and extramedullary disease relapse is a well-known occurrence in B-ALL pediatric patients treated with standard chemo-immunotherapy and, more recently, with chimeric antigen receptor (CAR)-T cell therapy. 18 F-Fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) emerges as a sensitive imaging tool for detecting disease relapse at extra-medullary sites, with only limited literature evidence in the CAR-T therapy setting. CASE REPORT: In a 12-year-old female treated with CAR-T therapy for B-ALL relapse, 18 F-FDG PET/CT scan performed for surveillance, after disease remission, detected a solitary and clinically occult relapse in the breast parenchyma that was histologically confirmed.
CONCLUSION
At our knowledge, this is the first report about a pediatric B-ALL patient with a solitary and occult breast relapse after CAR-T therapy, early discovered by 18 F-FDG PET/CT during disease monitoring.
论文信息
- 作者
- Perrone E、Taralli S、Pagliara D、Larocca LM、Vinti L、Leccisotti L
- 单位
- Nuclear Medicine Unit, Department of Diagnostic Imaging, Radiation Oncology and Hematology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.Italy
- 文献类型
- 病例报告
- 期刊
- Anticancer research2024 May
- 原文标识
- PubMed 38677722 · DOI 10.21873/anticanres.17032