RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
2023 年亮点：从基础研究到临床试验，NK 细胞抗肿瘤的重要性
英文原题：Highlight of 2023: From fundamental studies to clinical trials, the importance of NK cells against cancer.
查看英文原题
Highlight of 2023: From fundamental studies to clinical trials, the importance of NK cells against cancer.
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中文摘要
在2023年亮点系列的本篇文章中，我们探讨了各种因素如何影响自然杀伤（NK）细胞对抗肿瘤的能力。例如，肿瘤细胞可以通过减少表面突起或通过血小板增加HLA-E表达来阻碍NK细胞功能。与女性相比，男性NK细胞中UTX蛋白水平较低也会降低其细胞毒性。幸运的是，近期在治疗方法上取得了进展，包括开发了肿瘤微环境中NK细胞异质性的综合图谱，以及一种三特异性衔接分子，该分子在增强NK细胞抗肿瘤功能方面显示出前景。
展开英文摘要原文
In this article for the Highlights of 2023 Series, we discuss how various factors affect the ability of natural killer (NK) cells to fight tumors. For instance, tumor cells can hinder NK cell function by reducing surface protrusions or increasing HLA-E expression via platelets. Lower UTX protein levels in male NK cells also decrease their cytotoxicity compared with females.
Fortunately, recent advancements in therapeutic approaches have emerged, including the development of a comprehensive atlas of NK cell heterogeneity within the tumor microenvironment, as well as a trispecific engager molecule that has shown promise in enhancing the anti-tumor functions of NK cells.
论文信息
- 作者
- Bourel C、Lesage S
- 单位
- Immunologie-oncologie, Centre de recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada.Canada
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Immunology and cell biology2024 Jul
- 原文标识
- PubMed 38670548 · DOI 10.1111/imcb.12763