CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
实体瘤有效 CAR-T 细胞免疫治疗相关的挑战与策略
英文原题：Challenges and strategies in relation to effective CAR-T cell immunotherapy for solid tumors.
查看英文原题
Challenges and strategies in relation to effective CAR-T cell immunotherapy for solid tumors.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
CAR-T 细胞疗法已革新癌症治疗，但其在实体瘤中的应用仍受限。CAR-T 细胞难以进入肿瘤微环境，在其中存活、增殖并最终发挥功能的能力不足。本综述总结了提高 CAR-T 在实体瘤中的浸润、疗效、抗原识别和制备能力的主要策略，并讨论 CAR-T 与巨噬细胞的其他应用。我们认为，一旦这些问题得到解决，CAR-T 将成为实体瘤治疗的重要里程碑。
展开英文摘要原文
Chimeric Antigen Receptor T cell (CAR-T) therapy has revolutionized cancer treatment, but its application to solid tumors is limited. CAR-T cells have poor incapability of entering, surviving, proliferating, and finally exerting function in the tumor microenvironment. This review summarizes the main strategies related to enhancing the infiltration, efficacy, antigen recognition, and production of CAR-T in solid tumors. Additional applications of CAR- T and macrophages are also discussed.
We believe CAR-T will be a milestone in treating solid tumors once these problems are solved.
论文信息
- 作者
- Yuan G、Ye M、Zhang Y、Zeng X
- 第一作者单位
- State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.China
- 通讯作者单位
- State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China. xunzeng@zju.edu.cn.China
- 文献类型
- 综述
- 期刊
- Medical oncology (Northwood, London, England)2024 Apr 23
- 原文标识
- PubMed 38652178 · DOI 10.1007/s12032-024-02310-y