CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
提升实体瘤 CAR-T 细胞治疗安全性与特异性的合成生物学策略
英文原题：Synthetic biology approaches for enhancing safety and specificity of CAR-T cell therapies for solid cancers.
查看英文原题
Synthetic biology approaches for enhancing safety and specificity of CAR-T cell therapies for solid cancers.
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中文摘要
CAR-T 细胞疗法已成功治疗多种血液系统恶性肿瘤，因为T细胞可经工程化改造靶向疾病相关特定抗原。然而，CAR-T 疗法向实体癌转化更具挑战，原因包括缺乏真正肿瘤相关抗原以及脱靶毒性风险高。为应对这些问题，研究者正整合多种合成生物学机制，开发更安全、特异性更高、且可更精准时空调控的CAR-T 细胞。本文从合成生物学和免疫学角度总结并分析CAR-T 细胞疗法临床转化方面的进展。本综述可作为个体化细胞疗法领域进一步研究和发展的参考资料。
展开英文摘要原文
CAR-T cell therapies have been successful in treating numerous hematologic malignancies as the T cell can be engineered to target a specific antigen associated with the disease.
However, translating CAR-T cell therapies for solid cancers is proving more challenging due to the lack of truly tumor-associated antigens and the high risk of off-target toxicities. To combat this, numerous synthetic biology mechanisms are being incorporated to create safer and more specific CAR-T cells that can be spatiotemporally controlled with increased precision.
Here, we seek to summarize and analyze the advancements for CAR-T cell therapies with respect to clinical implementation, from the perspective of synthetic biology and immunology. This review should serve as a resource for further investigation and growth within the field of personalized cellular therapies.
论文信息
- 作者
- Russell GC、Hamzaoui Y、Rho D、Sutrave G、Choi JS、Missan DS、Reckard GA、Gustafson MP
- 第一作者单位
- Department of Physiology and Biomedical Engineering, Mayo Clinic Arizona, Scottsdale, Arizona, USA.United States
- 通讯作者单位
- Department of Physiology and Biomedical Engineering, Mayo Clinic Arizona, Scottsdale, Arizona, USA; Department of Immunology, Mayo Clinic Arizona, Scottsdale, Arizona, USA. Electronic address: kim.gloria2@mayo.edu.United States
- 文献类型
- 综述
- 期刊
- Cytotherapy2024 Aug
- 原文标识
- PubMed 38639669 · DOI 10.1016/j.jcyt.2024.03.484