RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
NK 细胞作为细胞免疫疗法在体内和体外口腔肿瘤清除与分化中的作用
英文原题：Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro.
查看英文原题
Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro.
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中文摘要
尽管癌症治疗领域取得了进展，口腔癌患者的五年生存率仍然很低。因此，需要针对口腔癌的有效治疗方法。此外，包括我们在内的多项研究表明，口腔癌患者中NK细胞的功能和数量受到严重抑制。在这篇综述中，我们讨论了通过直接杀伤或NK细胞介导的肿瘤分化来抑制肿瘤生长和转移的方法。本综述还概述了利用破骨细胞和益生菌增强NK细胞的方法，以及它们在人源化-BLT小鼠中作为癌症免疫治疗剂的疗效。
展开英文摘要原文
Despite advancements in the field of cancer therapeutics, the five-year survival rate remains low in oral cancer patients.
Therefore, the effective therapeutics are needed against oral cancer. Also, several studies including ours, have shown severely suppressed function and number of NK cells in oral cancer patients. In this review, we discuss the approach to inhibit the tumor growth and metastasis by direct killing or NK cell-mediated tumor differentiation. This review also provides an overview on supercharging NK cells using osteoclasts and probiotic bacteria, and their efficacy as cancer immunotherapeutic in humanized-BLT mice.
论文信息
- 作者
- Kaur K、Jewett A
- 第一作者单位
- Division of Oral Biology and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, University of California School of Dentistry, 10833 Le Conte Ave, 90095 Los Angeles, CA, USA.United States
- 通讯作者单位
- Division of Oral Biology and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, University of California School of Dentistry, 10833 Le Conte Ave, 90095 Los Angeles, CA, USA; The Jonsson Comprehensive Cancer Center, UCLA School of Dentistry and Medicine, Los Angeles, CA, USA.United States
- 文献类型
- 综述
- 期刊
- Critical reviews in immunology2024
- 原文标识
- PubMed 38618731 · DOI 10.1615/CritRevImmunol.2024052389