CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞竞赛：游戏规则
英文原题：The CAR T-cell race: The rules of the game.
查看英文原题
The CAR T-cell race: The rules of the game.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
对于符合tisagenlecleucel CAR-T 产品治疗条件的难治性急性淋巴细胞白血病儿童，从患者转诊到产品输注的整个流程涉及多个决策节点。如何结合患者个体情况、优化单采细胞产量，尤其是如何制定最佳桥接化疗方案，Kumar Mishra及其同事的这份全面实用建议作了清晰阐述。本文评述Mishra等人的《实践指南：B急性淋巴细胞白血病儿童及青年CAR-T 细胞治疗准备》。Br J Haematol. 2024;204:1687–1696。
展开英文摘要原文
The management of paediatric patients with refractory acute lymphoblastic leukaemia eligible for the CAR T cell product tisagenlecleucel involves multiple decision points between the process of patient referral to product infusion.
How to address the individual patient's circumstances, optimize apheresis yields and, above all, plan the best bridging chemotherapy is clearly detailed in these comprehensive and practical recommendations by Kumar Mishra and colleagues. Commentary on: Mishra et al. Practice guideline: Preparation for CAR T-cell therapy in children and young adults with B-acute lymphoblastic leukaemia. Br J Haematol 2024;204:1687-1696.
论文信息
- 作者
- Balduzzi A
- 单位
- Fondazione IRCCS San Gerardo dei Tintori, Hematopoietic Stem Cell Transplant Unit, Monza, Italy.Italy
- 期刊
- British journal of haematology2024 May
- 原文标识
- PubMed 38590088 · DOI 10.1111/bjh.19452