CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
免疫细胞-肿瘤微环境相互作用的生物物理与生物化学方面
英文原题：Biophysical and biochemical aspects of immune cell-tumor microenvironment interactions.
查看英文原题
Biophysical and biochemical aspects of immune cell-tumor microenvironment interactions.
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中文摘要
肿瘤微环境（TME）由异质性癌细胞和细胞外基质构成并受其影响，在癌症进展中发挥关键作用。TME的生物物理特征，即其结构和力学性质，会调节癌细胞与免疫细胞之间的相互作用及空间分布。本文综述促肿瘤、免疫抑制性应答相关的TME因素，尤其是细胞外基质以及肿瘤细胞和基质细胞。随后从生化和生物物理角度讨论先天性和适应性免疫系统细胞对肿瘤的应答，重点关注CD8⁺和CD4⁺ T细胞。在此基础上，文章进一步探讨基于免疫的抗肿瘤干预措施，特别是旨在改善CAR-T 细胞疗法的近期生物物理学突破。
展开英文摘要原文
The tumor microenvironment (TME), composed of and influenced by a heterogeneous set of cancer cells and an extracellular matrix, plays a crucial role in cancer progression. The biophysical aspects of the TME (namely, its architecture and mechanics) regulate interactions and spatial distributions of cancer cells and immune cells. In this review, we discuss the factors of the TME-notably, the extracellular matrix, as well as tumor and stromal cells-that contribute to a pro-tumor, immunosuppressive response.
We then discuss the ways in which cells of the innate and adaptive immune systems respond to tumors from both biochemical and biophysical perspectives, with increased focus on CD8+ and CD4+ T cells. Building upon this information, we turn to immune-based antitumor interventions-specifically, recent biophysical breakthroughs aimed at improving CAR-T cell therapy.
论文信息
- 作者
- Benmelech S、Le T、McKay M、Nam J、Subramaniam K、Tellez D、Vlasak G、Mak M
- 单位
- Department of Biomedical Engineering, Yale University, New Haven, Connecticut 06511, USA.United States
- 文献类型
- 综述
- 期刊
- APL bioengineering2024 Jun
- 原文标识
- PubMed 38572312 · DOI 10.1063/5.0195244
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