RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
HLA-G 在肿瘤及 COVID-19 感染中的作用
英文原题：Role of HLA-G in tumors and upon COVID-19 infection.
查看英文原题
Role of HLA-G in tumors and upon COVID-19 infection.
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中文摘要
肿瘤及病毒感染时 HLA-G 的表达参与其免疫逃逸，导致其逃避 T 细胞和 NK 细胞的识别。在这两种病理生理条件下，HLA-G 表达的潜在机制广泛，涵盖从遗传异常到表观遗传、转录和转录后调控。本综述总结了关于肿瘤性和病毒性转化后 HLA-G 表达的频率、调控及临床相关性的当前认识，其与微环境组分的相互作用，以及其作为诊断标志物和/或治疗靶点的潜力。此外，还讨论了 HLA-G 研究中必须解决的紧迫问题。
展开英文摘要原文
HLA-G expression of tumors and upon viral infections is involved in their immune escape leading to the evasion from both T and NK cell recognition. The underlying mechanisms of HLA-G expression in both pathophysiologic conditions are broad and range from genetic abnormalities to epigenetic, transcriptional and posttranscriptional regulation.
This review summarizes the current knowledge of the frequency, regulation and clinical relevance of HLA-G expression upon neoplastic and viral transformation, its interaction with components of the microenvironment as well as its potential as diagnostic marker and/or therapeutic target.
In addition, it discusses urgent topics, which have to be addressed in HLA-G research.
论文信息
- 作者
- Seliger B
- 单位
- Institute of Translational Immunology, Medical School "Theodor Fontane", 14770, Brandenburg an der Havel, Germany; Medical Faculty, Martin Luther University Halle-Wittenberg, 06112, Halle (Saale), Germany; Fraunhofer Institute for Cell Therapy and Immunology, 04103, Leipzig, Germany. Electronic address: barbara.seliger@uk-halle.de.Germany
- 文献类型
- 综述
- 期刊
- Human immunology2024 May
- 原文标识
- PubMed 38555250 · DOI 10.1016/j.humimm.2024.110792