RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
人乳头瘤病毒阳性头颈部鳞状细胞癌的免疫微环境
英文原题：Immune microenvironment of human papillomavirus-positive head and neck squamous cell carcinoma.
查看英文原题
Immune microenvironment of human papillomavirus-positive head and neck squamous cell carcinoma.
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研究概要
免疫微环境研究作为探索肿瘤的重要手段，在 HPV 阳性 HNSCC 研究中发挥了重要作用。我们通过分析 HNSCC 免疫微环境组分和免疫治疗对 HPV 阳性 HNSCC 的影响，描述 HNSCC 免疫微环境重要组分的生物学意义。可能为该疾病的实验研究和临床防治提供新策略。
研究思路结论见上方概要
目的
基于免疫微环境的人乳头瘤病毒（HPV）阳性头颈部鳞状细胞癌（HNSCC）研究进展。
方法
本文初步探讨了免疫微环境组分的构成与免疫治疗，并阐述和分析了HPV阳性HNSCC中T细胞、B细胞、自然杀伤（NK）细胞、肿瘤相关成纤维细胞和骨髓源性抑制细胞对肿瘤进展及预后的参与和影响。此外，还探讨了免疫相关治疗在HPV阳性HNSCC中的应用。
结果
研究发现，免疫微环境研究在HPV阳性HNSCC的发病机制和治疗中发挥重要作用。
展开英文摘要原文
OBJECTIVES
Research progress of human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) based on immune microenvironment.
METHODS
This article preliminarily discusses the composition of immune microenvironment components and immune therapy and elaborates and analyzes the involvement and impact of T cells, B cells, natural killer (NK) cells, tumor-associated fibroblasts, and bone marrow-derived suppressor cells in HPV-positive HNSCC on tumor progression and prognosis. Furthermore, the application of immune-related therapies in HPV-positive HNSCC is explored.
RESULTS
It is found that immune microenvironment research plays an important role in the pathogenesis and treatment of HPV-positive HNSCC.
CONCLUSIONS
Immune microenvironment research as an important means to explore tumors has played an important role in the study of HPV-positive HNSCC. We describe the biological significance of important components of HNSCC immune microenvironment by analyzing the effects of HNSCC immune microenvironment components and immunotherapy on HPV-positive HNSCC. May to provide new strategies for experimental research and clinical prevention and treatment of this disease.
论文信息
- 作者
- Zhu D、He X、Li Y、Li G、Chen M
- 单位
- State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau SAR, China.China
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Science progress2024 Jan-Mar
- 原文标识
- PubMed 38545800 · DOI 10.1177/00368504241237888
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