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宫颈癌和子宫内膜癌的免疫治疗:当前格局与未来方向

英文原题:Immunotherapy in Cervical and Endometrial Cancer: Current Landscape and Future Directions.

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Immunotherapy in Cervical and Endometrial Cancer: Current Landscape and Future Directions.

PubMed 2024/03/06(内容时间) Life (Basel) Q1 · IF 3.9(JCR 2025)

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中文摘要

进行了全面的文献检索,以确定相关研究和临床试验。简要描述了宫颈癌和子宫内膜癌免疫治疗中采用的主要方法和治疗手段,包括免疫检查点抑制剂、癌症疫苗和过继细胞疗法。

免疫检查点抑制剂,如抗PD-1/PD-L1抗体,在某些妇科恶性肿瘤中显示出显著的临床疗效,尤其是在晚期或复发病例中。此外,关于癌症疫苗和过继细胞疗法的持续研究为个性化和靶向治疗选择带来了希望。

展开英文摘要原文

Gynecological cancers pose a significant burden on women's health worldwide, necessitating innovative treatment approaches. Immunotherapy has emerged as a promising strategy, harnessing the body's immune system to combat cancer. This review aims to provide a comprehensive overview of the current landscape and future directions of immunotherapy in cervical and endometrial cancer. Methods: A thorough literature search was conducted to identify relevant studies and clinical trials.

The main methods and treatments employed in immunotherapy for cervical and endometrial cancer, including immune checkpoint inhibitors, cancer vaccines, and adoptive cell therapies, are briefly described. Results: Immune checkpoint inhibitors, such as anti-PD-1/PD-L1 antibodies, have shown remarkable clinical efficacy in certain gynecological malignancies, particularly in advanced or recurrent cases.

Additionally, ongoing research on cancer vaccines and adoptive cell therapies holds promise for personalized and targeted treatment options.

论文信息

作者
Stefanoudakis D、Karopoulou E、Matsas A、Katsampoula GA、Tsarna E、Stamoula E、Christopoulos P
单位
Second Department of Obstetrics and Gynecology, Aretaieion University Hospital, Medical School, National and Kapodistrian University of Athens, 76 Vasilissis Sofias Avenue, 11528 Athens, Greece.Bulgaria
文献类型
综述
期刊
Life (Basel, Switzerland)2024 Mar 6
原文标识
PubMed 38541669 · DOI 10.3390/life14030344