PROTAC 工程化蛋白/DNA 纳米抗原是癌症免疫治疗中树突状细胞疫苗的有效增强剂
PROTAC-Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Potential role of immune cell therapy in gynecological cancer and future promises: a comprehensive review.
Potential role of immune cell therapy in gynecological cancer and future promises: a comprehensive review.
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妇科恶性肿瘤是全世界女性最主要的死亡原因之一。妇科恶性肿瘤的高患病率仍然显著,因此需要转向免疫治疗等新型治疗方法,即通过免疫系统的侵入来杀死癌细胞。近年来,免疫治疗已成为一种较为先进的治疗方法,通过激活免疫系统来抑制肿瘤细胞的存活、增殖和侵袭。此外,包括 T 细胞、B 细胞和树突状细胞在内的多种免疫细胞均与癌症治疗中的免疫治疗策略相关。尽管 T 细胞抗肿瘤的重要作用已被充分证实,但 B 细胞和树突状细胞也通过调节免疫系统在不同妇科癌症中发挥重要作用。本综述聚焦于该领域,并强调免疫细胞在妇科癌症治疗中的作用。多种基于免疫细胞的抗癌疗法,如 T 细胞疗法、过继性细胞转移、B 细胞疗法以及树突状细胞疗法的方法,均已详细讨论。此外,近期研究还综述并阐明了妇科癌症免疫治疗的临床背景和未来方向。
Gynecological malignancies are most leading causes of death among women worldwide. The high prevalence of gynecologic malignancies remains significant, necessitating to turn the novel treatment approach like immunotherapy, wherein cancer cells are killed by the invasion of immune system. In recent year, immunotherapy has mostly an advanced treatment approach to repressing the tumor cells survival, proliferation, and invasion via the activation of immune systems.
Moreover, various types of immune cells including T-cells, B-cells, and dendritic cells are associated with the immunotherapeutic strategy in cancer treatment. Although the significant role of T-cells against cancer is well established, while B-cells and dendritic cells also play an important role against different gynecological cancer by regulating the immune system.
This review focuses on that arena and highlight the role of immune cells in the treatment of gynaecological cancer. Various immune cell-based anticancer therapies such as T-cell therapies, Adoptive Cellular transfer, B-cell therapies as well as approaches to Dendritic Cell therapies have been discussed in detail.
Furthermore, the clinical settings and future avenues regarding immunotherapy on gynecological cancer have also been reviewed and illuminated in the recent study.
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