CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
难治性眼眶浆细胞瘤经 CAR-T 细胞治疗成功：一例病例报告及文献复习
英文原题：Successful Treatment of Refractory Orbital Plasmacytoma with Chimeric Antigen Receptor T Cell Therapy: A Case Report and Review of the Literature.
查看英文原题
Successful Treatment of Refractory Orbital Plasmacytoma with Chimeric Antigen Receptor T Cell Therapy: A Case Report and Review of the Literature.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
眼眶浆细胞瘤是一种罕见的浆细胞肿瘤，可能作为髓外多发性骨髓瘤的侵袭性形式出现。治疗方式包括手术切除、放疗和化疗。CAR-T 细胞疗法目前保留用于难治性疾病。作者报告了一例69岁女性，患有广泛眼眶浆细胞瘤，对多模式治疗难治，接受了idecabtagene vicleucelCAR-T 细胞疗法。输注后四天，患者出现1级细胞因子释放综合征，经tocilizumab治疗后缓解。治疗后1个月，眼眶浆细胞瘤显著缩小，并在10个月随访时显示完全血清学反应和持续的肿瘤负荷减少。本病例突出了CAR-T 细胞疗法对难治性眼眶浆细胞瘤的疗效，并提醒注意潜在的炎症毒性。
展开英文摘要原文
Orbital plasmacytoma is a rare plasma cell tumor that may arise as an aggressive form of extramedullary multiple myeloma. Treatment modalities include surgical excision, radiation, and chemotherapy. Chimeric antigen receptor T cell therapy is currently reserved for refractory disease. The authors present a case of a 69-year-old woman with an extensive orbital plasmacytoma refractory to multimodal therapy who was treated with idecabtagene vicleucel chimeric antigen receptor T cell therapy.
Four days after infusion, the patient exhibited grade 1 cytokine release syndrome, which resolved with tocilizumab. The orbital plasmacytoma significantly decreased in size 1 month after treatment and demonstrated complete serological response and sustained tumor burden reduction at 10-month follow-up. This case highlights the efficacy of chimeric antigen receptor T cell therapy for refractory orbital plasmacytoma and calls attention to potential inflammatory toxicities.
论文信息
- 作者
- Lin RZ、Lu T、Homer N、Men CJ
- 第一作者单位
- Department of Ophthalmology & Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, U.S.A.United States
- 通讯作者单位
- Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, U.S.A.United States
- 文献类型
- 病例报告 · 综述
- 期刊
- Ophthalmic plastic and reconstructive surgery2024 Jul-Aug 01
- 原文标识
- PubMed 38534054 · DOI 10.1097/IOP.0000000000002651