CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Quantification of CD3, FoxP3, and granzyme B immunostaining in canine renal cell carcinoma.
Quantification of CD3, FoxP3, and granzyme B immunostaining in canine renal cell carcinoma.
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TIL（肿瘤浸润淋巴细胞）密度在抗肿瘤免疫中发挥重要作用，并与多种人类和犬类恶性肿瘤的患者预后相关。作为对犬肾细胞癌（RCC）肿瘤微环境免疫景观的首次评估，我们回顾性分析了临床数据，并对16只接受输尿管肾切除术治疗的肾细胞癌患犬的福尔马林固定石蜡包埋肿瘤样本中的CD3、FoxP3和颗粒酶B免疫染色进行了定量。所有评估标志物的细胞密度均较低。瘤内FoxP3标记（+）细胞数量增加，以及颗粒酶B+: FoxP3+ TIL比值降低，与患者不良预后相关。我们对犬RCC的初步研究揭示，这些肿瘤在免疫学上属于冷肿瘤，Tregs可能在免疫逃逸中发挥重要作用。
Tumor-infiltrating lymphocyte (TIL) density plays an important role in anti-tumor immunity and is associated with patient outcome in various human and canine malignancies. As a first assessment of the immune landscape of the tumor microenvironment in canine renal cell carcinoma (RCC), we retrospectively analyzed clinical data and quantified CD3, FoxP3, and granzyme B immunostaining in formalin-fixed paraffin-embedded tumor samples from 16 dogs diagnosed with renal cell carcinoma treated with ureteronephrectomy.
Cell density was low for all markers evaluated. Increased numbers of intratumoral FoxP3 labelled (+) cells, as well as decreased granzyme B+: FoxP3+ TIL ratio, were associated with poor patient outcomes.
Our initial study of canine RCC reveals that these tumors are immunologically cold and Tregs may play an important role in immune evasion.
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