CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
ASCT 联合 CAR-T 治疗多发性骨髓瘤的进展与展望
英文原题：Progress and prospect of ASCT combined with CAR-T therapy in the treatment of multiple myeloma.
查看英文原题
Progress and prospect of ASCT combined with CAR-T therapy in the treatment of multiple myeloma.
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中文摘要
多发性骨髓瘤（MM）是一种以骨髓中浆细胞异常增殖为特征的血液系统肿瘤。近年来，自体干细胞移植（ASCT）已成为MM治疗的基石。与此同时，免疫治疗如单克隆抗体治疗和CAR-T 细胞也已兴起，其中CAR-T 是最受关注的焦点。ASCT及其清髓性预处理会使其免疫微环境转变为抑制状态，这可能为CAR-T 细胞的扩增提供机会，从而进一步清除ASCT后的残留病灶并降低ASCT后的复发率。同时，输注CAR-T 细胞可加速骨髓瘤ASCT后的细胞免疫重建，从而提高抗肿瘤效果。为探讨其临床价值，本文就ASCT联合CAR-T 治疗MM的进展与前景作一综述。
展开英文摘要原文
Multiple myeloma (MM) is a hematological cancer characterized by abnormal proliferation of plasma cells in bone marrow. In recent years, autologous stem cell transplantation (ASCT) has become the cornerstone of MM treatment. At the same time, immunotherapy, such as monoclonal antibody therapy and chimeric antigen receptor T cell (CAR-T) has also emerged, in which CAR-T is the most attractive focus.
ASCT and its myeloablative preconditioning will turn its immune microenvironment into an inhibited state, which may provide an opportunity for the expansion of CAR-T cells so as to further clear the residual lesions after ASCT and reduce the recurrence rate after ASCT.
Meanwhile, the infusion of CAR-T cells can accelerate the cellular immune reconstruction after ASCT of myeloma, thereby improving the antitumor effect. In order to explore the clinic value, this article reviews the progress and prospect of ASCT combined with CAR-T therapy in the treatment of MM.
论文信息
- 作者
- Yuan S、Chen Y、Liu H
- 第一作者单位
- Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.China
- 通讯作者单位
- Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Road, Xi'an, Shaanxi, P.R. China.China
- 文献类型
- 综述
- 期刊
- Therapeutic advances in hematology2024
- 原文标识
- PubMed 38481949 · DOI 10.1177/20406207241237594
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