RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
固有免疫细胞：调控肿瘤微环境（TME）交响乐中的关键演奏者
英文原题：Innate immune cells: Key players of orchestra in modulating tumor microenvironment (TME).
查看英文原题
Innate immune cells: Key players of orchestra in modulating tumor microenvironment (TME).
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中文摘要
肿瘤微环境（TME）在癌症进展中起着至关重要的作用，由内皮细胞、免疫细胞和间充质干细胞等多种细胞组成。特别是，巨噬细胞、树突状细胞、髓源性抑制细胞、中性粒细胞、固有淋巴细胞、γδT淋巴细胞和NK 细胞等固有免疫细胞在TME中存在时，既可促进也可抑制肿瘤进展。对TME与固有免疫细胞之间交互作用研究的增加，将为抗肿瘤治疗干预带来新方法。本综述主要聚焦于固有免疫细胞的生物学及其在TME中的主要功能。此外，还总结了目前正在临床试验中测试的几种基于固有免疫的免疫疗法。
展开英文摘要原文
The tumor microenvironment (TME) with vital role in cancer progression is composed of various cells such as endothelial cells, immune cells, and mesenchymal stem cells. In particular, innate immune cells such as macrophages, dendritic cells, myeloid-derived suppressor cells, neutrophils, innate lymphoid cells, γδT lymphocytes, and natural killer cells can either promote or suppress tumor progression when present in the TME.
An increase in research on the cross-talk between the TME and innate immune cells will lead to new approaches for anti-tumoral therapeutic interventions. This review primarily focuses on the biology of innate immune cells and their main functions in the TME.
In addition, it summarizes several innate immune-based immunotherapies that are currently tested in clinical trials.
论文信息
- 作者
- Sadeghi M、Dehnavi S、Sharifat M、Amiri AM、Khodadadi A
- 单位
- Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Iran
- 文献类型
- 综述
- 期刊
- Heliyon2024 Mar 15
- 原文标识
- PubMed 38463798 · DOI 10.1016/j.heliyon.2024.e27480
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