CELL INTELLIGENCE · 肿瘤细胞治疗研究

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提高 CAR-T 细胞治疗免疫治疗效果的先进策略

英文原题：Advanced strategies in improving the immunotherapeutic effect of CAR-T cell therapy.

查看英文原题

Advanced strategies in improving the immunotherapeutic effect of CAR-T cell therapy.

PubMed 2024/03/08（内容时间） Mol Oncol Q2 · IF 4.5（JCR 2025）

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技术：CAR-T血液系统恶性肿瘤实体瘤地区：中国
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中文摘要

嵌合抗原受体（CAR-T）细胞疗法是一种新开发的免疫治疗策略，在血液系统恶性肿瘤的治疗中取得了令人满意的效果。然而，在CAR-T 细胞疗法作为癌症治疗方法广泛应用于临床之前，一些与CAR-T 细胞疗法相关的不良反应必须得到解决。此外，CAR-T 细胞疗法在实体瘤治疗中的应用受到诸多限制的阻碍。因此，探索新的策略以提高CAR-T 细胞疗法的治疗效果至关重要。在这篇综述中，我们总结了近期开发的旨在优化CAR-T 细胞生成和提高CAR-T 细胞疗法抗肿瘤效率的策略。此外，还重点介绍了CAR-T 细胞疗法新靶点的发现以及CAR-T 细胞疗法与化疗、放疗、癌症疫苗和纳米材料联合治疗的策略。

展开英文摘要原文

Chimeric antigen receptor (CAR-T) cell therapy is a newly developed immunotherapy strategy and has achieved satisfactory outcomes in the treatment of hematological malignancies.

However, some adverse effects related to CAR-T cell therapy have to be resolved before it is widely used in clinics as a cancer treatment.

Furthermore, the application of CAR-T cell therapy in the treatment of solid tumors has been hampered by numerous limitations.

Therefore, it is essential to explore novel strategies to improve the therapeutic effect of CAR-T cell therapy. In this review, we summarized the recently developed strategies aimed at optimizing the generation of CAR-T cells and improving the anti-tumor efficiency of CAR-T cell therapy.

Furthermore, the discovery of new targets for CAR-T cell therapy and the combined treatment strategies of CAR-T cell therapy with chemotherapy, radiotherapy, cancer vaccines and nanomaterials are highlighted.

论文信息

作者
Wang M、Jia L、Dai X、Zhang X
单位
Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, First Hospital of Jilin University, Changchun, China.China
文献类型
综述 · 非美国政府资助研究
期刊
Molecular oncology2024 Aug
原文标识
PubMed 38456710　·　DOI 10.1002/1878-0261.13621

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