CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
超越 CAR-T 的实体瘤过继细胞治疗：当前挑战与新兴治疗进展
英文原题：Adoptive cell therapy for solid tumors beyond CAR-T: Current challenges and emerging therapeutic advances.
查看英文原题
Adoptive cell therapy for solid tumors beyond CAR-T: Current challenges and emerging therapeutic advances.
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中文摘要
利用表达嵌合抗原受体（CARs）的免疫细胞进行的过继性细胞免疫治疗是一种高度特异性的抗肿瘤免疫治疗，已在血液系统恶性肿瘤的治疗中显示出前景。然而，由于复杂的肿瘤微环境影响 CAR 细胞的定位和杀伤能力，实体瘤的治疗进展缓慢。具有强免疫抑制微环境和复杂血管系统的实体瘤不受 CAR 细胞浸润和攻击的影响。为了提高其对实体瘤的疗效，CAR 细胞已通过装饰和修剪进行了改造和升级。本综述聚焦于 CARs 的结构和功能、可被 CARs 改造的免疫细胞以及克服实体瘤的改造策略，以期拓宽 CAR 细胞疗法更好应用于实体瘤治疗的思路。
展开英文摘要原文
Adoptive cellular immunotherapy using immune cells expressing chimeric antigen receptors (CARs) is a highly specific anti-tumor immunotherapy that has shown promise in the treatment of hematological malignancies.
However, there has been a slow progress toward the treatment of solid tumors owing to the complex tumor microenvironment that affects the localization and killing ability of the CAR cells. Solid tumors with a strong immunosuppressive microenvironment and complex vascular system are unaffected by CAR cell infiltration and attack.
To improve their efficacy toward solid tumors, CAR cells have been modified and upgraded by "decorating" and "pruning". This review focuses on the structure and function of CARs, the immune cells that can be engineered by CARs and the transformation strategies to overcome solid tumors, with a view to broadening ideas for the better application of CAR cell therapy for the treatment of solid tumors.
论文信息
- 作者
- Zhang T、Tai Z、Miao F、Zhang X、Li J、Zhu Q、Wei H、Chen Z
- 第一作者单位
- Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200443, China; Medical Guarantee Center, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China; School of Medicine, Shanghai University, Shanghai 200444, China; Shanghai Engineering Research Center for Topical Chinese Medicine, Shanghai 200443, China.China
- 通讯作者单位
- Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200443, China; School of Medicine, Shanghai University, Shanghai 200444, China; Shanghai Engineering Research Center for Topical Chinese Medicine, Shanghai 200443, China. Electronic address: aajian818@163.com.China
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Journal of controlled release : official journal of the Controlled Release Society2024 Apr
- 原文标识
- PubMed 38408567 · DOI 10.1016/j.jconrel.2024.02.033