CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
血液恶性肿瘤中 CAR-T 细胞治疗相关挑战与策略
英文原题：Challenges and strategies associated with CAR-T cell therapy in blood malignancies.
查看英文原题
Challenges and strategies associated with CAR-T cell therapy in blood malignancies.
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中文摘要
细胞免疫治疗，尤其是 CAR-T 细胞，已在改善血液系统难治性和复发性恶性肿瘤患者的结局方面显示出潜力。然而，对于血液癌症，实现可持续的长期完全缓解仍然是一项挑战，耐药和复发是许多患者的预期结局。尽管许多研究试图阐明 CAR-T 细胞治疗失败的机制，但其机制仍不清楚。在本文中，我们讨论并描述关于这些因素的当前知识状态，这些因素包括影响 CAR-T 细胞、作为整体的癌细胞以及肿瘤周围微环境的因素。此外，我们提出了克服这些障碍的前瞻性方法，以努力降低复发率并延长 CAR-T 细胞治疗后患者的生存期。
展开英文摘要原文
Cellular immunotherapy, particularly CAR-T cells, has shown potential in the improvement of outcomes in patients with refractory and recurrent malignancies of the blood.
However, achieving sustainable long-term complete remission for blood cancer remains a challenge, with resistance and relapse being expected outcomes for many patients. Although many studies have attempted to clarify the mechanisms of CAR-T cell therapy failure, the mechanism remains unclear. In this article, we discuss and describe the current state of knowledge regarding these factors, which include elements that influence the CAR-T cell, cancer cells as a whole, and the microenvironment surrounding the tumor.
In addition, we propose prospective approaches to overcome these obstacles in an effort to decrease recurrence rates and extend patient survival subsequent to CAR-T cell therapy.
论文信息
- 作者
- Liu Z、Lei W、Wang H、Liu X、Fu R
- 第一作者单位
- Department of Hematology, Tianjin Medical University General Hospital, 154 Anshan Street, Heping District, Tianjin, 300052, PR China. liuzhaoyun114@163.com.China
- 通讯作者单位
- Department of Hematology, Tianjin Medical University General Hospital, 154 Anshan Street, Heping District, Tianjin, 300052, PR China. furong8369@tmu.edu.cn.China
- 文献类型
- 综述
- 期刊
- Experimental hematology & oncology2024 Feb 24
- 原文标识
- PubMed 38402232 · DOI 10.1186/s40164-024-00490-x
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