非常规 T 细胞在泌尿系统肿瘤中：能抓住就抓住
Unconventional T cells in urological cancers: catch them if you can.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
膀胱癌根治性膀胱切除术后 TIL（肿瘤浸润淋巴细胞）的预后价值：系统综述与荟萃分析
英文原题：The Prognostic Value of Tumor Infiltrating Lymphocytes After Radical Cystectomy for Bladder Cancer: A Systematic Review and Meta-Analysis.
查看英文原题
The Prognostic Value of Tumor Infiltrating Lymphocytes After Radical Cystectomy for Bladder Cancer: A Systematic Review and Meta-Analysis.
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研究概要
TIL 是接受 RC 治疗的 BC 患者中有用的预后标志物。尽管 TIL 的预后价值因亚群和浸润部位而异，但 CD8+ TIL 和瘤内 TIL 与肿瘤学结局相关。需要进一步研究来阐明 TIL 对围手术期全身治疗反应的预测价值，以帮助 BC 患者的临床决策。
研究思路结论见上方概要
背景
我们旨在评估TIL（肿瘤浸润淋巴细胞）（TILs）对膀胱癌（BC）患者行根治性膀胱切除术（RC）后的预后价值。
方法
我们在2022年4月检索了Pubmed、Web of Science和Scopus，以识别评估RC后TILs（包括淋巴细胞亚群，如CD3、CD8、FOXP3）预后价值的研究。终点为总生存期和无复发生存期。根据TILs的评估方法（即CD3、CD8、FOXP3、HE染色）进行了亚组分析。
结果
总体而言，本meta分析共纳入9项研究、1413例患者。meta分析显示，TILs高表达与有利的OS（合并风险比[HR]：0.65，95%置信区间[CI]：0.51-0.83）和RFS（合并HR：0.48，95% CI：0.35-0.64）显著相关。在亚组分析中，高CD8+ TILs也与有利的OS（HR：0.51，95% CI：0.33-0.80）和RFS（合并HR：0.53，95% CI：0.36-0.76）相关。在纳入146例患者的3项研究中，高瘤内TILs与有利的OS显著相关（合并HR：0.34，95% CI：0.19-0.60）。
展开英文摘要原文
BACKGROUND
We aimed to assess the prognostic value of tumor infiltrating lymphocytes (TILs) in patients with bladder cancer (BC) after radical cystectomy (RC).
MATERIALS AND METHODS
We searched Pubmed, Web of Science and Scopus in April 2022 to identify studies assessing the prognostic value of TILs, including a subset of lymphocytes (eg, CD3, CD8, FOXP3), after RC. The endpoints were overall survival and recurrent free survival. Subgroup analyses were performed based on the evaluation method for TILs (ie, CD3, CD8, FOXP3, HE staining).
RESULTS
Overall, 9 studies comprising 1413 patients were included in this meta-analysis. The meta-analysis revealed that elevated expressions of TILs were significantly associated with favorable OS (pooled hazard ratio [HR]: 0.65, 95% confidence interval [CI]: 0.51-0.83) and RFS (pooled HR: 0.48, 95% CI: 0.35-0.64). In subgroup analyses, high CD8+ TILs were also associated with favorable OS (HR: 0.51, 95% CI: 0.33-0.80) and RFS (pooled HR: 0.53, 95% CI: 0.36-0.76). Among 3 studies comprising 146 patients, high intratumoral TILs were significantly associated with favorable OS (pooled HR: 0.34, 95% CI: 0.19-0.60).
CONCLUSION
TILs are useful prognostic markers in patients treated with RC for BC. Although the prognostic value of TILs is varied, depending on the subset and infiltration site, CD8+ TILs and intratumoral TILs are associated with oncologic outcomes. Further studies are warranted to explicate the predictive value of TILs on the response to perioperative systemic therapy to help clinical decision-making in patients with BC.
论文信息
- 作者
- Kawada T、Yanagisawa T、Rajwa P、Motlagh RS、Mostafaei H、Quhal F、Laukhtina E、Pallauf M
- 第一作者单位
- Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita-ku, Okayama, Japan.Austria
- 通讯作者单位
- Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Hourani Center for Applied Scientific Research, Al-Ahliyya Amman University, Amman, Jordan; Department of Urology, University of Texas Southwestern, Dallas, Texas, USA; Department of Urology, Second Faculty of Medicine, Charles University, Prag, Czech Republic; Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria; Research Center for Evidence Medicine, Urology Department Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: shahrokh.shariat@meduniwien.ac.at.Austria
- 文献类型
- 荟萃分析 · 系统综述 · 非美国政府资助研究
- 期刊
- Clinical genitourinary cancer2024 Apr
- 原文标识
- PubMed 38336572 · DOI 10.1016/j.clgc.2024.01.008