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通过单细胞测序理解 CAR-T 细胞治疗应答机制:见解与挑战

英文原题:Understanding Mechanisms of Response to CAR T-cell Therapy through Single-Cell Sequencing: Insights and Challenges.

查看英文原题

Understanding Mechanisms of Response to CAR T-cell Therapy through Single-Cell Sequencing: Insights and Challenges.

PubMed 2024/03/01(内容时间) Blood Cancer Discov Q1 · IF 12.2(JCR 2025)

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中文摘要

单细胞RNA测序已成为一种强大的技术,用于理解与临床结果相关的嵌合抗原受体(CAR)T细胞的分子特征。在此,我们讨论了CAR-T 细胞疗法单细胞研究中出现的共同主题,并总结了解读这种复杂数据类型的挑战。

展开英文摘要原文

Single-cell RNA sequencing has emerged as a powerful technique to understand the molecular features of chimeric antigen receptor (CAR) T cells that associate with clinical outcomes. Here we discuss the common themes that have emerged from across single-cell studies of CAR T-cell therapy, and summarize the challenges in interpreting this complex data type.

论文信息

作者
Haradhvala NJ、Maus MV
单位
Broad Institute of Harvard and MIT, Cambridge, Massachusetts.United Kingdom
期刊
Blood cancer discovery2024 Mar 1
原文标识
PubMed 38324393 · DOI 10.1158/2643-3230.BCD-23-0212