CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
泛癌分析揭示了 RAMPs 的预后价值和免疫相关性
英文原题：Pan-cancer analysis revealed prognosis value and immunological relevance of RAMPs.
查看英文原题
Pan-cancer analysis revealed prognosis value and immunological relevance of RAMPs.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
受体活性修饰蛋白（RAMPs）是否在人类癌症预后和免疫中发挥关键作用仍不清楚。我们使用了来自公共数据库The Cancer Genome Atlas、Therapeutically Applicable Research to Generate Effective Treatments和Genotype-Tissue Expression project的数据。
我们利用生物信息学方法、R软件和多种在线数据库分析RAMPs。总体而言，RAMPs在多种肿瘤中显著且差异表达，RAMP表达与预后、免疫检查点、RNA编辑基因、肿瘤突变负荷、微卫星不稳定性、倍性和干性指数密切相关。
此外，RAMPs的表达与人类癌症中的TIL（肿瘤浸润淋巴细胞）强烈相关。而且，RAMP共表达网络在很大程度上参与许多免疫相关生物学过程。定量逆转录聚合酶链反应和Western blot证明RAMP3在胶质瘤中高表达，且RAMP3促进肿瘤增殖和迁移。RAMPs表现出作为人类癌症预后和免疫相关生物标志物的潜力。
此外，RAMPs可潜在开发为治疗靶点或用于增强免疫治疗的疗效。
展开英文摘要原文
Whether receptor activity-modifying proteins (RAMPs) play a key role in human cancer prognosis and immunity remains unknown.
We used data from the public databases, The Cancer Genome Atlas, Therapeutically Applicable Research to Generate Effective Treatments, and the Genotype-Tissue Expression project.
We utilized bioinformatics methods, R software, and a variety of online databases to analyze RAMPs. In general, RAMPs were significantly and differentially expressed in multiple tumors, and RAMP expression was closely associated with prognosis, immune checkpoints, RNA-editing genes, tumor mutational burden, microsatellite instability, ploidy, and stemness indices.
In addition, the expression of RAMPs is strongly correlated with tumor-infiltrating lymphocytes in human cancers.
Moreover, the RAMP co-expression network is largely involved in many immune-related biological processes. Quantitative reverse transcription polymerase chain reaction and Western blot proved that RAMP3 was highly expressed in glioma, and RAMP3 promoted tumor proliferation and migration. RAMPs exhibit potential as prognostic and immune-related biomarkers in human cancers.
Moreover, RAMPs can be potentially developed as therapeutic targets or used to enhance the efficacy of immunotherapy.
论文信息
- 作者
- Yang S、Huan R、Deng M、Luo T、Peng S、Xiong Y、Han G、Liu J
- 第一作者单位
- Guizhou University Medical College, Guiyang, 550025, Guizhou Province, China.China
- 通讯作者单位
- Department of Neurosurgery, Guizhou Provincial People's Hospital, Guiyang, China.China
- 期刊
- Heliyon2024 Feb 15
- 原文标识
- PubMed 38317990 · DOI 10.1016/j.heliyon.2024.e24849
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →