提升 NK 细胞治疗卵巢癌的疗效（综述）

Ovarian cancer is a prevalent gynecological malignancy associated with a high mortality rate and a low 5 year survival rate. Typically, >70% of patients present with an advanced stage of the disease, resulting in a high number of ovarian cancer associated deaths worldwide.

Over the past decade, adoptive cellular immunotherapy has been investigated in clinical trials, and the results have led to the increased use in cancer treatment. Natural killer (NK) cells are cytotoxic lymphoid cells that recognize and lyse transformed cells, thereby impeding tumor growth.

Thus, NK cells exhibit potential as a form of immunotherapy in the treatment of cancer.

However, some patients with ovarian cancer treated with NK cells have experienced unsatisfactory outcomes.

Therefore, further optimization of NK cells is required to increase the number of patients achieving long term remission. In the present review article, studies focusing on improving NK cell function were systematically summarized, and innovative strategies that augment the anticancer properties of NK cells were proposed.