CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
体内生物发光与荧光成像：肿瘤研究的光学工具
英文原题：In Vivo Bioluminescence and Fluorescence Imaging: Optical Tool for Cancer Research.
查看英文原题
In Vivo Bioluminescence and Fluorescence Imaging: Optical Tool for Cancer Research.
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中文摘要
利用生物发光和荧光检测等光学工具开展体内全身成像，可在测试动物体内特异性地确定癌细胞的时空分布。这使研究癌细胞增殖、迁移和侵袭等多个方面成为可能。该方法还可在同一动物不同时间点监测多种受试化合物（例如用于癌症免疫治疗的CD19 CAR-T 细胞）的抗肿瘤治疗效果，从而显著减少实验动物使用量。
展开英文摘要原文
In vivo whole-body imaging, using optical tools based on bioluminescence and fluorescence detection, offers tremendous opportunities to specifically determine the spatiotemporal resolution of cancer cells within the tested animals. This enables the study of many aspects of cancer biology, including cell proliferation, trafficking, and invasions.
The antitumor therapeutic properties of various tested compounds (e. g. , CD19 CAR-T cells, used for cancer immunotherapy) can be monitored within the same animal at different time points, significantly reducing the number of animals used in the study as indicated in this method.
论文信息
- 作者
- Lainšček D、Golob-Urbanc A、Orehek S
- 单位
- Department of Synthetic Biology and Immunology, National Institute of Chemistry, Ljubljana, Slovenia. dusko.lainscek@ki.si.
- 文献类型
- 非美国政府资助研究
- 期刊
- Methods in molecular biology (Clifton, N.J.)2024
- 原文标识
- PubMed 38236541 · DOI 10.1007/978-1-0716-3714-2_11