CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
TNF-α 与电离辐射：在浆细胞骨髓瘤发病机制与治疗中的作用（综述）
英文原题：TNF-α AND IONIZING RADIATION: THE ROLE IN THE PATHOGENESIS AND TREATMENT OF PLASMA CELL MYELOMA (review).
查看英文原题
TNF-α AND IONIZING RADIATION: THE ROLE IN THE PATHOGENESIS AND TREATMENT OF PLASMA CELL MYELOMA (review).
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
该综述呈现了关于肿瘤坏死因子（TNF-）和电离辐射（IR）在浆细胞骨髓瘤（PCM）发病机制和治疗中作用的文献数据。分析了该细胞因子功能调节的紊乱，这种紊乱在负面外部因素（包括电离辐射IR）影响下，影响免疫系统与基质浆细胞的相互作用。介绍了利用最新技术治疗该疾病的现代方向，特别是CAR-T 细胞疗法，这将有助于未来优化该疾病的治疗，从而提高PCM患者的生活质量和预期寿命。
展开英文摘要原文
The review presents data from the literature on the role of Tumor necrosis factor- (TNF- ) and ionizing radiation (IR) in the pathogenesis and treatment of plasma cell myeloma (PCM). There was analyzed disturbance of regulation of functioning of this cytokine, which affects the interaction of the immune system with substrate plasma cells under the influence of negative external factors, including ionizing radiation IR.
Modern directions of therapy of this disease using the latest technologies are presented, in particular CAR T-cell therapy, which will allow to optimize in the future treatment of this disease and, thus, improve the quality and life expectancy of PCM patients. - (TNF- ) . , , . , CAR - , , , .
论文信息
- 作者
- Liubarets TF
- 单位
- Bogomolets National Medical University, 13 Tarasa Shevchenko Blvd, Kyiv, 01601, Ukraine.
- 文献类型
- 综述
- 期刊
- Problemy radiatsiinoi medytsyny ta radiobiolohii2023 Dec
- 原文标识
- PubMed 38155115 · DOI 10.33145/2304-8336-2023-28-65-74