CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
通过检测磷酸盐与镁水平早期预测 CAR-T 细胞治疗后的细胞因子释放综合征
英文原题：Early prediction of cytokine release syndrome by measuring phosphate and magnesium levels following chimeric antigen receptor T cell therapy.
查看英文原题
Early prediction of cytokine release syndrome by measuring phosphate and magnesium levels following chimeric antigen receptor T cell therapy.
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研究概要
48 小时内 IP 和 Mg 浓度的变化可能是 CRS 发作的有用预测标志物。
研究思路结论见上方概要
背景
细胞因子释放综合征（CRS）是CAR-T（CAR-T）细胞疗法的一种危及生命的副作用。本研究探讨了血清无机磷酸盐（IP）和镁（Mg）水平是否为CRS发生的预测标志物。
方法
这项单中心回顾性队列研究连续纳入了16例接受CAR-T 细胞治疗的弥漫大B细胞淋巴瘤患者。采用广义估计方程的logistic回归模型，评估IP和Mg水平较基线值的变化是否与48小时内发生CRS相关。
结果
IP 和 Mg 水平较基线下降（每变化 10%）与 CRS 发生率升高相关（校正比值比分别为 2.18 [95% CI, 1.31-3.62]、3.18 [95% CI, 1.57-6.44]）。
展开英文摘要原文
METHODS
This single-center retrospective cohort study enrolled 16 consecutive patients with diffuse large B-cell lymphoma who had received CAR-T cell therapy. Logistic regression models with generalized estimating equations were used to evaluate whether changes in IP and Mg levels from their baseline values were associated with the development of CRS within 48 hours.
RESULTS
Decreased IP and Mg levels from baseline (per 10% change) were associated with an increased CRS incidence (adjusted odds ratio 2.18 [95% confidence interval (CI), 1.31-3.62], 3.18 [95% CI, 1.57-6.44], respectively).
CONCLUSIONS
Changes in IP and Mg concentrations within 48 hours may be useful predictive markers of CRS onset.
论文信息
- 作者
- Yoshida M、Matsuoka Y、Mitsuyuki S、Yonetani N、Kawai J、Kondo T、Ishikawa T
- 第一作者单位
- Department of Clinical Laboratory, Kobe City Medical Center General Hospital, Kobe, Japan.Japan
- 通讯作者单位
- Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan.Japan
- 期刊
- Blood cell therapy2023 Nov 25
- 原文标识
- PubMed 38149020 · DOI 10.31547/bct-2023-021
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