CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
胃癌免疫微环境与免疫治疗的研究进展
英文原题：Research progress on the immune microenvironment and immunotherapy in gastric cancer.
查看英文原题
Research progress on the immune microenvironment and immunotherapy in gastric cancer.
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中文摘要
肿瘤微环境，尤其是免疫微环境，在胃癌（GC）的恶性进展和转移中发挥着不可或缺的作用。随着我们对GC微环境认识的不断深入，我们在单细胞水平上对其生物学机制有了更深入的了解。这反过来又为GC治疗提供了新的视角。令人鼓舞的是，目前有多种单药和联合疗法正在应用中，例如免疫检查点抑制剂、过继性细胞转移疗法、CAR-T 细胞疗法、抗体-药物偶联物和癌症疫苗。本文综述了目前关于GC微环境的研究进展，并总结了有前景的免疫治疗研究和靶向治疗。
展开英文摘要原文
The tumor microenvironment, particularly the immune microenvironment, plays an indispensable role in the malignant progression and metastasis of gastric cancer (GC). As our understanding of the GC microenvironment continues to evolve, we are gaining deeper insights into the biological mechanisms at the single-cell level. This, in turn, has offered fresh perspectives on GC therapy.
Encouragingly, there are various monotherapy and combination therapies in use, such as immune checkpoint inhibitors, adoptive cell transfer therapy, chimeric antigen receptor T cell therapy, antibody-drug conjugates, and cancer vaccines. In this paper, we review the current research progress regarding the GC microenvironment and summarize promising immunotherapy research and targeted therapies.
论文信息
- 作者
- Mou P、Ge QH、Sheng R、Zhu TF、Liu Y、Ding K
- 第一作者单位
- Changzheng Hospital of Naval Medical University, Shanghai, China.China
- 通讯作者单位
- Department of Gastroenterology, Changzheng Hospital of Naval Medical University, Shanghai, China.China
- 文献类型
- 综述
- 期刊
- Frontiers in immunology2023
- 原文标识
- PubMed 38077373 · DOI 10.3389/fimmu.2023.1291117
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