CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
与 TIL（肿瘤浸润淋巴细胞）高表达和低表达相关的磁共振成像特征：按分子亚型的分层分析
英文原题：Magnetic Resonance Imaging Features Associated with a High and Low Expression of Tumor-Infiltrating Lymphocytes: A Stratified Analysis According to Molecular Subtypes.
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Magnetic Resonance Imaging Features Associated with a High and Low Expression of Tumor-Infiltrating Lymphocytes: A Stratified Analysis According to Molecular Subtypes.
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中文摘要
本研究共分析457例患者，包括241例HR+/HER2−患者、134例HER2+患者和82例三阴性（TN）患者。采用10%为界值评估肿瘤细胞邻近间质中的TIL比例。HR+、HER2+和TN患者中TIL比例较低者分别占82%、63%和56%（p<0.001）。评估的MRI特征包括肿块或非肿块强化（NME）形态、形状、边缘、内部强化、瘤周水肿是否存在以及动态对比增强（DCE）动力学模式。HR+/HER2−组肿瘤体积较小（p<0.001）；HER2+肿瘤更可能表现为NME（p=0.031）；均匀强化多见于HR+患者（p<0.001）；瘤周水肿在HR+、HER2+和TN患者中的发生率分别为45%、71%和80%（p<0.001）。研究在各亚型内比较了高TIL组与低TIL组的MR特征。在HR+/HER2−患者中，高TIL者更可能出现瘤周水肿（70%），而低TIL者为40%（p<0.001）。在TN患者中，高TIL者更可能表现为规则形状（33%），低TIL者为13%（p=0.029）；高TIL者也更可能表现为边界清楚（19%），低TIL者为2%（p=0.009）。
展开英文摘要原文
A total of 457 patients, including 241 HR+/HER2- patients, 134 HER2+ patients, and 82 TN patients, were studied. The percentage of TILs in the stroma adjacent to the tumor cells was assessed using a 10% cutoff. The low TIL percentages were 82% in the HR+ patients, 63% in the HER2+ patients, and 56% in the TN patients ( p < 0. 001). MRI features such as morphology as mass or non-mass enhancement (NME), shape, margin, internal enhancement, presence of peritumoral edema, and the DCE kinetic pattern were assessed. Tumor sizes were smaller in the HR+/HER2- group ( p < 0. 001); HER2+ was more likely to present as NME ( p = 0.
031); homogeneous enhancement was mostly seen in HR+ ( p < 0. 001); and the peritumoral edema was present in 45% HR+, 71% HER2+, and 80% TN ( p < 0. 001). In each subtype, the MR features between the high- vs. low-TIL groups were compared.
In HR+/HER2-, peritumoral edema was more likely to be present in those with high TILs (70%) than in those with low TILs (40%, p < 0. 001). In TN, those with high TILs were more likely to present a regular shape (33%) than those with low TILs (13%, p = 0. 029) and more likely to present the circumscribed margin (19%) than those with low TILs (2%, p = 0. 009).
论文信息
- 作者
- Zhou J、Jin Y、Miao H、Lu S、Liu X、He Y、Liu H、Zhao Y
- 第一作者单位
- Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.China
- 通讯作者单位
- Department of Radiological Sciences, University of California, Irvine, CA 92697, USA.United States
- 期刊
- Cancers2023 Nov 30
- 原文标识
- PubMed 38067374 · DOI 10.3390/cancers15235672
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