RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
哺乳动物雷帕霉素靶蛋白与结直肠癌关系的生物信息学分析
英文原题：Bio Informatics Analysis of the Relationship Between Mammalian Target of Rapamycin and Colorectal Cancer.
查看英文原题
Bio Informatics Analysis of the Relationship Between Mammalian Target of Rapamycin and Colorectal Cancer.
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研究概要
基于这些发现，我们将 mTOR 视作结直肠癌诊断和预后的生物标志物。
中文摘要
目的
本研究旨在通过研究哺乳动物雷帕霉素靶蛋白（mTOR）及结直肠癌生物信息学分析，促进我国结直肠癌临床治疗并挽救患者生命。
方法
利用Coad及癌症基因组图谱（TCGA）公开数据库数据，分析mTOR表达及生存差异，并探讨mTOR共表达调控网络。使用Linked Omics数据库筛选mTOR调控的miRNA。此外，研究还考察mTOR与药物敏感性、免疫细胞相关性、微卫星缺失、肿瘤突变负荷及突变分析之间的关系。
结果
结直肠癌中mTOR表达及生存差异具有统计学意义，并与博来霉素、顺铂和吉西他滨敏感性有关。mTOR与树突状细胞活化、NK细胞静息、树突状细胞静息及嗜酸性粒细胞相关。mTOR还与微卫星缺失及肿瘤突变负荷相关。
结论
基于这些发现，我们认为mTOR可作为结直肠癌诊断和预后的生物标志物。
展开英文摘要原文
OBJECTIVE
The purpose of this paper is to promote the medical treatment of colorectal cancer in our country and to save the lives of patients with colorectal cancer by studying mammalian target of rapamycin (mTOR) and the biologic information analysis of colorectal cancer.
METHODS
We analyzed mTOR expression and survival differences using data from Coad & read from the TCGA public database and explored the coexpression regulatory network of mTOR. mTOR-regulated mirnas were screened using the Linked Omics database. In addition, we explored the association of mTOR with drug sensitivity, immune cell correlations, microsatellite deletions, tumor mutational burden, and mutational analysis.
RESULTS
The expression and survival of mTOR were significant different in colorectal cancer, and were related to the sensitivity of Bleomycin, Cisplatin and Gemcitabine. mTOR is associated with dendritic cell activation, NK cell dormancy, dendritic cell dormancy, and eosinophil granulocyte. mTOR is associated with microsatellite deletions, and tumor mutational load.
CONCLUSIONS
Based on these findings, we consumer mTOR as a biomarker for the diagnosis and prognosis of colorectal cancer.
论文信息
- 作者
- Han L、Lin L、Chen J、Yan B
- 单位
- Key Laboratory of Translational Oncology, Putian University, Putian, CN.
- 期刊
- Studies in health technology and informatics2023 Nov 23
- 原文标识
- PubMed 38007756 · DOI 10.3233/SHTI230856