间皮素作为癌症免疫治疗的生物标志物和治疗靶点
Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer.
癌症仍是一个关键的全球健康问题，原因在于发现晚、耐药和高死亡率。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
EBV 相关性胃癌的内镜诊断与治疗
英文原题：Endoscopic Diagnosis and Therapy for Epstein-Barr Virus-Associated Gastric Cancer.
查看英文原题
Endoscopic Diagnosis and Therapy for Epstein-Barr Virus-Associated Gastric Cancer.
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中文摘要
EBV相关胃癌（EBVaGC）占所有GC的近7%，是GC的一种独特亚型，具有极端的DNA高甲基化。EBVaGC是一种TIL（肿瘤浸润淋巴细胞）丰富的肿瘤，早期淋巴结转移少，晚期预后相对较好。通过上消化道内镜检查，我们将EBVaGC识别为主要位于胃上部、靠近胃黏膜萎缩边界或残胃的凹陷型病变，伴有SMT样隆起。以内镜特征为线索的EBVaGC识别率为21.4%，并不高，EBVaGC的内镜诊断仍需进一步进展。作为一种创伤较小的内镜治疗，对于淋巴结转移少的早期EBVaGC，应讨论扩大内镜黏膜下剥离术（ESD）的适应证标准。EBVaGC的内镜诊断可能与筛选可从内镜治疗或化疗中获益的患者相关。
展开英文摘要原文
Epstein-Barr-virus-associated gastric cancer (EBVaGC) represents almost 7% of all GC and is a distinct subtype of GC with extreme DNA hypermethylation. EBVaGC is a tumor-infiltrating lymphocyte-rich tumor with little lymph-node metastasis in its early stage and with a relatively favorable prognosis in its advanced stage. Using upper gastrointestinal endoscopy, we recognize EBVaGC as a mainly depressed type with SMT-like protrusion in the upper part of the stomach near the gastric mucosal atrophic border or remnant stomach.
The EBVaGC recognition rate of 21. 4% with the endoscopic motif is not high, and further progress in endoscopic diagnosis of EBVaGC is needed. As less invasive endoscopic therapy, the extension of the criteria of endoscopic submucosal dissection (ESD) for early EBVaGC with little lymph-node metastasis should be discussed. Endoscopic diagnosis of EBVaGC may be relevant for the selection of patients who could benefit from endoscopic treatment or chemotherapy.
论文信息
- 作者
- Yanai H、Fujiwara J、Toyama E、Okuda H、Miura O、Kaino S、Nishikawa J
- 第一作者单位
- Department of Clinical Research, Hofu Institute of Gastroenterology, 14-33 Ekiminami, Hofu 747-0801, Yamaguchi, Japan.Japan
- 通讯作者单位
- Department of Laboratory Science, Yamaguchi University Graduate School of Medicine, 1-1-1Minamikogushi, Ube 755-8505, Yamaguchi, Japan.Japan
- 期刊
- Microorganisms2023 Oct 24
- 原文标识
- PubMed 38004633 · DOI 10.3390/microorganisms11112619
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