CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
抗 B 细胞成熟抗原 CAR-T 细胞治疗 AL 淀粉样变性及合并复发/难治性多发性骨髓瘤：初步疗效和安全性
英文原题：Anti-B Cell Maturation Antigen Chimeric Antigen Receptor T Cell Therapy for the Treatment of AL Amyloidosis and Concurrent Relapsed/Refractory Multiple Myeloma: Preliminary Efficacy and Safety.
查看英文原题
Anti-B Cell Maturation Antigen Chimeric Antigen Receptor T Cell Therapy for the Treatment of AL Amyloidosis and Concurrent Relapsed/Refractory Multiple Myeloma: Preliminary Efficacy and Safety.
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中文摘要
CAR-T 疗法和双特异性抗体等免疫疗法已革新多发性骨髓瘤（MM）的治疗，但由于担心潜在自主神经、心脏及肾功能障碍会导致致命毒性，伴AL型淀粉样变的患者一直被排除在这些疗法的临床试验之外。本文报告两例同时患有AL型淀粉样变和MM并伴有心脏和/或肾功能障碍的患者接受抗BCMA CAR-T 治疗的结局；患者接受ide-cel或cilta-cel治疗，并进行细胞因子释放综合征预防。两人均良好耐受治疗，毒性可控，并达到微小残留病灶阴性状态。我们报告CAR-T 用于AL型淀粉样变患者的初步疗效和安全性，并强调治疗前选择患者及优化心肾功能的重要性。
展开英文摘要原文
While immunotherapies, such as CAR T therapy and bi-specific antibodies, have revolutionized the treatment of multiple myeloma (MM), patients with AL amyloidosis have been excluded from trials with these agents due to concerns of underlying autonomic, cardiac, and renal dysfunction, leading to potentially fatal toxicities from these therapies.
In this communication, we described the outcomes of two patients with AL amyloidosis and concurrent MM with underlying cardiac and/or renal dysfunction who underwent anti-BCMA CAR T cell therapy with ide-cel or cilta-cel, received cytokine release syndrome prophylaxis, and tolerated therapy well with manageable toxicities and achieved a MRD-negative state.
We described the preliminary efficacy and safety of CAR T in patients with AL amyloidosis and highlighted the importance of patient selection and medical optimization of cardiac and renal function prior to CAR T.
论文信息
- 作者
- Das S、Ailawadhi S、Sher T、Roy V、Fernandez A、Parrondo RD
- 单位
- Division of Hematology-Oncology and Blood and Marrow Transplantation Program, Mayo Clinic, Jacksonville, FL 32224, USA.United States
- 文献类型
- 病例报告
- 期刊
- Current oncology (Toronto, Ont.)2023 Oct 31
- 原文标识
- PubMed 37999117 · DOI 10.3390/curroncol30110697
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