CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
促进 CAR-T 细胞向实体瘤迁移与浸润的研究进展
英文原题：Advances in promoting chimeric antigen receptor T cell trafficking and infiltration of solid tumors.
查看英文原题
Advances in promoting chimeric antigen receptor T cell trafficking and infiltration of solid tumors.
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中文摘要
经工程改造表达嵌合抗原受体（CAR）的T细胞治疗血液系统恶性肿瘤已显示出很高的缓解率。然而，实体瘤存在多重挑战，限制CAR-T 细胞的抗肿瘤疗效，包括抗原异质性、肿瘤外及全身毒性，以及免疫抑制性肿瘤微环境（TME）。值得注意的是，实体瘤TME存在趋化因子失调，结构致密，由肿瘤基质、细胞外基质和异常血管构成，阻碍CAR-T 细胞迁移至肿瘤部位并浸润实体瘤组织。本综述重点介绍促进CAR-T 细胞向实体瘤迁移和浸润的近期进展，以增强CAR-T 细胞对抗原的有效识别。
展开英文摘要原文
T cells engineered to express chimeric antigen receptors (CARs) have demonstrated robust response rates in treating hematological malignancies.
However, solid tumors present multiple challenges that hinder the antitumor efficacy of CAR-T cells, including antigen heterogeneity, off-tumor and systemic toxicities, and the immunosuppressive milieu of the tumor microenvironment (TME).
Notably, the TME of solid tumors is characterized by chemokine dysregulation and a dense architecture consisting of tumor stroma, extracellular matrix, and aberrant vasculature that impede migration of CAR-T cells to the tumor site as well as infiltration into the solid-tumor mass. In this review, we highlight recent advances to improve CAR-T-cell trafficking to and infiltration of solid tumors to promote effective antigen recognition by CAR-T cells.
论文信息
- 作者
- Hong M、Talluri S、Chen YY
- 第一作者单位
- Department of Chemical and Biomolecular Engineering, University of California-Los Angeles, Los Angeles, CA 90095, USA.United States
- 通讯作者单位
- Department of Chemical and Biomolecular Engineering, University of California-Los Angeles, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology, and Molecular Genetics, University of California-Los Angeles, Los Angeles, CA 90095, USA; Parker Institute for Cancer Immunotherapy Center at UCLA, Los Angeles, CA 90095, USA. Electronic address: yvchen@ucla.edu.United States
- 文献类型
- 综述
- 期刊
- Current opinion in biotechnology2023 Dec
- 原文标识
- PubMed 37976958 · DOI 10.1016/j.copbio.2023.103020