CD81 通过阻断 CD274/PD-L1 的选择性自噬降解驱动放射抵抗性胶质母细胞瘤的免疫逃逸
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
靶向免疫原性细胞死亡用于胶质瘤免疫治疗
英文原题：Targeting immunogenic cell death for glioma immunotherapy.
查看英文原题
Targeting immunogenic cell death for glioma immunotherapy.
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中文摘要
免疫原性细胞死亡（ICD）在靶向胶质瘤——最常见的原发性脑肿瘤——以实现增强免疫治疗方面引起了极大兴趣。我们讨论了ICD诱导Th17免疫这一意外发现，并提出基于树突状细胞（DC）疫苗的最佳设计，该疫苗负载ICD诱导剂处理后获得的全胶质瘤裂解物。
展开英文摘要原文
Immunogenic cell death (ICD) arouses great interest in targeting glioma, the most common primary brain tumor, to achieve boosted immunotherapy. We discuss the unexpected findings on the induction of Th17 immunity by ICD and propose the best design for dendritic cell (DC)-based vaccines loaded with whole glioma lysates obtained after ICD inducers.
论文信息
- 作者
- Mishchenko TA、Turubanova VD、Gorshkova EN、Krysko O、Vedunova MV、Krysko DV
- 第一作者单位
- Institute of Biology and Biomedicine, National Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.Russia
- 通讯作者单位
- Cell Death Investigation and Therapy Laboratory, Anatomy and Embryology Unit, Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent, Ghent, Belgium. Electronic address: dmitri.krysko@ugent.be.Belgium
- 期刊
- Trends in cancer2024 Jan
- 原文标识
- PubMed 37973489 · DOI 10.1016/j.trecan.2023.10.005