CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
表位碱基编辑：非恶性干细胞进行伪装
英文原题：Epitope base editing: Non-malignant stem cells are going undercover.
查看英文原题
Epitope base editing: Non-malignant stem cells are going undercover.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
工程化造血干细胞可通过伪装躲避靶向免疫治疗。Casirati等人近期在《Nature》发表研究，采用单碱基编辑，改变急性髓系白血病和正常造血中涉及的表位，从而改变抗体及嵌合抗原受体（CAR）T细胞对这些表位的识别，同时保留其配体结合能力和酶功能。
展开英文摘要原文
Engineered hematopoietic stem cells can be shielded from targeted immunotherapy. Recently published in Nature, Casirati et al. utilized single-base editing of epitopes implicated in acute myeloid leukemia and healthy hematopoiesis to alter their antibody and chimeric antigen receptor (CAR) T recognition while preserving their ligand binding and enzymatic function.
论文信息
- 作者
- Saniei S、Wagenblast E
- 第一作者单位
- Department of Oncological Sciences, Tisch Cancer Institute, Black Family Stem Cell Institute, Mindich Child Health & Development Institute and Department of Pediatrics, Division of Pediatric Hematology-Oncology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, NY 10029, USA.United States
- 通讯作者单位
- Department of Oncological Sciences, Tisch Cancer Institute, Black Family Stem Cell Institute, Mindich Child Health & Development Institute and Department of Pediatrics, Division of Pediatric Hematology-Oncology, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, NY 10029, USA. Electronic address: elvin.wagenblast@mssm.edu.United States
- 期刊
- Cell stem cell2023 Nov 2
- 原文标识
- PubMed 37922877 · DOI 10.1016/j.stem.2023.09.009